Comparing early and delayed extubation after endovascular treatment for stroke
Optimal Ventilation Time After Endovascular Treatment Under General Anesthesia for Acute Ischemic Stroke. a Prospective, Randomized Comparison Between Early Vs Delayed Extubation
This study tests whether taking patients off a breathing machine sooner or later after stroke treatment helps them recover better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 174 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hospital Clinico Universitario de Santiago Academic / other |
| Locations | 1 site (Santiago de Compostela, A Coruña) |
| Trial ID | NCT05847309 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the impact of early extubation (within 6 hours) versus delayed extubation (6-12 hours) on the neurological functional status of patients who have undergone endovascular treatment for acute ischemic stroke under general anesthesia. The study will assess patients' outcomes at three months post-procedure using the modified Rankin scale (mRS). By comparing these two extubation strategies, the trial seeks to determine which approach leads to better recovery outcomes for stroke patients. Participants will be adults with acute ischemic stroke due to large vessel occlusion who have received satisfactory reperfusion.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with acute ischemic stroke due to large vessel occlusion who have undergone endovascular treatment under general anesthesia.
Not a fit: Patients who have not been intubated during the procedure or those with conditions such as pregnancy or bronchial aspiration may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved recovery outcomes for stroke patients undergoing endovascular treatment.
How similar studies have performed: Previous studies have suggested benefits of different anesthesia techniques in stroke treatment, but this specific comparison of extubation timing is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult (age ≥ 18 years) * Acute ischemic stroke due to large intracranial vessel occlusion demonstrated on CT-angiography in the following anterior circulation locations (occlusion of the internal carotid artery and/or middle cerebral artery in segments M1, M2, M3) within 24 hours of symptom onset. * Patients admitted with a NIHSS neurological status ≥ 6. * Patients who received endovascular treatment under general anesthesia (intubated in the interventional radiology room) with satisfactory reperfusion (TICI 2b-2c-3). * Patients admitted in the intensive care unit (ICU) with mechanical ventilation. * Written informed consent from the patient or proxy (if present) before inclusion or once possible when patient has been included in a context of emergency. Exclusion Criteria: * Patients who have not been intubated in the interventional radiology room. * Pregnancy * Patients who suffer bronchial aspiration prior to the endovascular procedure or during intubation. * Patients who underwent the procedure under local anesthesia and sedation. * Patients with functional neurological status, prior to the ischemic stroke, measured with the modified Rankin scale (mRS) of value: 3-6. * Patients with vascular involvement of the posterior cerebral circulation, or intracranial haemorrhage associated with stroke. * Patients who do not sign the informed consent by themselves or their relatives.
Where this trial is running
Santiago de Compostela, A Coruña
- University Clinical Hospital of Santiago de Compostela — Santiago de Compostela, A Coruña, Spain (Recruiting)
Study contacts
- Principal investigator: Manuel Taboada, Ph.D. — Clinical University Hospital of Santiago de Compostela
- Study coordinator: Manuel Taboada, Ph.D.
- Email: manutabo@yahoo.es
- Phone: 0034981950674
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.