Comparing different treatment durations for Helicobacter pylori eradication

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness and safety of dual and quadruple treatment regimens for Helicobacter pylori eradication over varying durations of 7, 10, and 14 days. Participants will be randomly assigned to receive either a dual regimen of vonoprazan and amoxicillin or a quadruple regimen that includes vonoprazan, amoxicillin, tetracycline, and bismuth. The success of the treatment will be assessed using a 13C-urea breath test six weeks after completion of the regimen, with a focus on eradication rates, adverse reactions, and patient adherence.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients aged 18-70 years old
2. Patients with H.pylori infection (13C/14C-urea breath test)
3. Patients without previous treatment for H. pylori eradication

Exclusion Criteria:

1. Patients with serious underlying diseases, such as liver insufficiency (Aspartate aminotransferase or alanine aminotransferase greater than the normal value), renal insufficiency (Cr≥2.0mg/dL or glomerular filtration rate \<50 ml/min), immunosuppression, malignant tumors, Coronary heart disease or coronary artery stenosis ≥75%
2. Patients with active gastrointestinal bleeding
3. Patients with a history of upper gastrointestinal surgery
4. Patients allergic to treatment drugs
5. Patients with medication history of bismuth, antibiotics within 4 weeks, or proton pump inhibitor within 2 weeks
6. Patients who are pregnant or lactating or unwilling to take contraceptive measures during the trial
7. Patients with other behaviors that may increase the risk of illness, such as alcohol and drug abuse
8. Patients who are unwilling or incapable to provide informed consents

Where it's running

• Qilu Hospital of Shandong University
  Jinan, Shandong, China Recruiting

Study contacts

• Study coordinator: Yanqing Li, Ph.D
• Email: liyanqing@sdu.edu.cn
• Phone: +8653188369277

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Dual vonoprazan and amoxicillin therapy for Helicobacter pylori infection in Uruguay

  This trial tests whether a two-drug regimen (vonoprazan and amoxicillin for 14 days) can be as effective as the standard four-drug regimen for eradicating H. pylori in adults in Uruguay, with fewer side effects.

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• Adding bismuth to vonoprazan‑amoxicillin therapy for H. pylori

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• Registry for managing Helicobacter pylori infection in Shandong Province

  This registry will collect real-world information on H. pylori treatments given to adults in Shandong Province to see which approaches work best and are safest.

  Recruiting Qilu Hospital of Shandong University · Jinan, Shandong and 1 other locations · NCT07335406

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.