Endoscopic screening for H. pylori, intestinal metaplasia, and Barrett's mucosa during screening colonoscopy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study enrolling adults aged 30 and older who are scheduled for screening or surveillance colonoscopy and do not have upper gastrointestinal symptoms. Participants who consent will undergo a simultaneous gastroscopy (OGD) with biopsy sampling to test for H. pylori and to document intestinal metaplasia and Barrett's mucosa. The study will record the prevalence of H. pylori and correlate infection status with other histologic findings and clinical risk factors. Patients with prior H. pylori treatment, recent PPI use, or pre-existing GI disease are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 30 years
* Scheduled screening colonoscopy (either initial screening or surveillance following previously detected polyps)
* Asymptomatic (no gastrointestinal symptoms)
* Willingness and consent to undergo simultaneous gastroscopy with biopsy sampling
* Written informed consent to participate in the study, including the use of histological findings and patient data for study analysis

Exclusion Criteria:

* Known Helicobacter pylori infection or previous treatment for H. pylori
* Current or recent proton pump inhibitor (PPI) therapy (\< 4 weeks)
* Pre-existing gastrointestinal diseases (e.g., chronic gastritis, ulcer, gastric carcinoma)
* Immunosuppression or relevant underlying diseases
* Refusal to undergo additional gastroscopy or biopsy

Where it's running

• Wiener Privatklinik (WPK)
  Vienna, Austria Recruiting

Study contacts

• Study coordinator: Harald Rosen, Univ. Prof. Dr.
• Email: rosensurg@csi.com
• Phone: +43 664 4422571

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.