Comparing blood transfusion thresholds in patients on ECMO

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the safety and efficacy of restrictive versus liberal thresholds for red blood cell transfusion in patients undergoing extracorporeal membrane oxygenation (ECMO). The research aims to determine whether a restrictive transfusion strategy can be safely applied to this vulnerable population, which often experiences anemia and requires transfusions. By comparing outcomes between the two approaches, the study seeks to provide evidence-based guidelines for transfusion practices in ECMO patients. The study will involve patients aged 18 and older who are currently receiving ECMO support.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient is aged 18 years or older;
* Is receiving ECMO;
* (Deferred) informed consent.

Exclusion Criteria:

* Not expected to survive for 24 hours when assessed;
* Inability to receive blood products;
* (Known) decline to blood transfusions (e.g., Jehovah's Witnesses);
* Extracorporeal carbon dioxide removal (ECCO2R) using low blood flow devices or pumpless devices (i.e., MINILUNG ®, PrismaLung+);
* Received ECMO over 48h before screening for eligibility.

Where it's running

• MedUni Wien
  Vienna, State of Vienna, Austria Recruiting
• Hôpital Erasme
  Brussels, Brussels Capital, Belgium Recruiting
• KU Leuven, medical IC
  Leuven, Flemish Brabant, Belgium Recruiting
• KU Leuven, surgical IC
  Leuven, Flemish Brabant, Belgium Recruiting
• CHU Charleroi
  Charleroi, Hainaut, Belgium Recruiting
• Medisch Spectrum Twente (MST)
  Enschede, Drenthe, Netherlands Recruiting

Study contacts

• Principal investigator: Alexander P.J. Vlaar, PhD — Amsterdam UMC, location AMC
• Study coordinator: Alexander P.J. Vlaar, PhD
• Email: a.p.vlaar@amsterdamumc.nl
• Phone: 020 566 9111

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.