Comparing blood purification methods in children with sepsis

Clinical Features and Outcomes of Continuous Blood Purification Versus Non-continuous Blood Purification in Pediatric Patients With Sepsis or Septic Shock

This study is testing if starting continuous blood purification early can help children with sepsis recover better and reduce organ damage.

Quick facts

• Study type: Observational
• Enrollment: 90 (estimated)
• Ages: 28 Days to 18 Years
• Sex: All
• Sponsor: Children's Hospital of Fudan University (Academic / other)
• Locations: 1 site (Shanghai, Shanghai Municipality)
• Trial ID: NCT04794595 on ClinicalTrials.gov

What this trial studies

This observational study investigates the effects of continuous blood purification (CBP) in children diagnosed with sepsis or septic shock. It aims to explore the efficacy of CBP and the optimal timing for its application to improve patient outcomes. By removing inflammatory factors and enhancing immune response, the study seeks to determine how early intervention with CBP can mitigate organ damage and restore immune balance in affected children.

Who should consider this trial

Good fit: Ideal candidates for this study are children aged 29 days to 18 years who have been diagnosed with sepsis and require blood purification.

Not a fit: Patients with a history of a PICU stay of less than 24 hours or those experiencing active bleeding may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment protocols for septic children, potentially reducing morbidity and mortality associated with sepsis.

How similar studies have performed: While the effects of CBP in adults have been explored, this specific approach in pediatric sepsis is still being investigated, making it a novel area of research.

Eligibility criteria

Inclusion Criteria:

* Age of 29d to 18 years old;
* Children diagnosed with sepsis requiring blood purification.

Exclusion Criteria:

* with a history of a duration of PICU stay \<24 h
* active bleeding, including cerebral hemorrhage

Where this trial is running

Shanghai, Shanghai Municipality

• Children'S Hospital of Fudan University — Shanghai, Shanghai Municipality, China (Recruiting)

Study contacts

• Principal investigator: Lu guoing — Children's Hospital of Fudan University
• Study coordinator: Ying Jiayun

Conditions Sepsis; Children, Only; Continuous renal replacement therapy; sepsis; timing