Comparing blood purification methods in children with sepsis
Official title: Clinical Features and Outcomes of Continuous Blood Purification Versus Non-continuous Blood Purification in Pediatric Patients With Sepsis or Septic Shock
Run by Children's Hospital of Fudan University · NCT04794595 · Data updated 2026-11-12
This study is testing if starting continuous blood purification early can help children with sepsis recover better and reduce organ damage.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 28 Days to 18 Years |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | Children's Hospital of Fudan University Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | December 1, 2020 |
| Main results expected | December 30, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | March 16, 2026 |
| Trial ID | NCT04794595 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are children aged 29 days to 18 years who have been diagnosed with sepsis and require blood purification.
✕Probably not a fit
Patients with a history of a PICU stay of less than 24 hours or those experiencing active bleeding may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the effects of continuous blood purification (CBP) in children diagnosed with sepsis or septic shock. It aims to explore the efficacy of CBP and the optimal timing for its application to improve patient outcomes. By removing inflammatory factors and enhancing immune response, the study seeks to determine how early intervention with CBP can mitigate organ damage and restore immune balance in affected children.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment protocols for septic children, potentially reducing morbidity and mortality associated with sepsis.
How similar studies have gone: While the effects of CBP in adults have been explored, this specific approach in pediatric sepsis is still being investigated, making it a novel area of research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age of 29d to 18 years old; * Children diagnosed with sepsis requiring blood purification. Exclusion Criteria: * with a history of a duration of PICU stay \<24 h * active bleeding, including cerebral hemorrhage
Where it's running
-
Children'S Hospital of Fudan University
Shanghai, Shanghai Municipality, China Recruiting
Study contacts
- Principal investigator: Lu guoing — Children's Hospital of Fudan University
- Study coordinator: Ying Jiayun
- Email: jiayundoctor@163.com
- Phone: 18817583962
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.