Comparing blood pressure management strategies after stroke treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial aims to evaluate different blood pressure (BP) management strategies in patients who have experienced an acute ischemic stroke and undergone endovascular therapy (EVT). It will randomize up to 2,000 patients with elevated systolic blood pressure (SBP) to receive conservative, moderate, or intensive BP control. The goal is to determine which approach leads to better functional outcomes and minimizes risks such as intracranial hemorrhage. The study is part of a larger adaptive platform trial designed to test multiple treatments for stroke simultaneously.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years;
2. Use of endovascular therapy (EVT) within 24 hours of symptom onset or last known well according to local guidelines;
3. Sustained high systolic blood pressure ≥150 mmHg (2 readings \<10 mins apart) within 3 hours after completion of EVT.

Exclusion Criteria:

1.Any definite contraindications to BP lowering treatment.

Where it's running

• The George Institute for Global Health
  Sydney, New South Wales, Australia Recruiting
• University of Calgary
  Calgary, Alberta, Canada Recruiting

Study contacts

• Principal investigator: Craig Anderson, PhD — The George Institute
• Study coordinator: Xiaoying Chen, PhD
• Email: xchen@georgeinstitute.org.au
• Phone: +61 2 8052 4549

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.