Comparing bariatric surgery and medical therapy for metabolic syndrome in low BMI patients
Army Medical University
This study is testing whether bariatric surgery or medical therapy works better for people with low BMI who have metabolic syndrome.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Third Military Medical University Academic / other |
| Locations | 1 site (Chongqing, Chongqing Municipality) |
| Trial ID | NCT05363059 on ClinicalTrials.gov |
What this trial studies
This observational study evaluates the effects of bariatric surgery versus medical therapy on metabolic syndrome in patients with a low body mass index (BMI). It includes a retrospective analysis of 200 patients, with 100 undergoing bariatric surgery and 100 receiving medical therapy, all meeting the diagnostic criteria for metabolic syndrome. The study tracks changes in metabolic syndrome components, cardiovascular disease risk, and medication use over a five-year follow-up period. The surgical procedures assessed include Roux-en-Y gastric bypass and sleeve gastrectomy, while the medical therapy group follows specific guidelines for managing obesity and type 2 diabetes.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with metabolic syndrome and a BMI less than 35 kg/m².
Not a fit: Patients with insulin-dependent diabetes, severe mental illness, or other significant comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into more effective treatment options for metabolic syndrome in patients with low BMI.
How similar studies have performed: While bariatric surgery has been shown to improve metabolic syndrome in obese patients, this specific comparison in low BMI patients is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
1. Inclusion Criteria: * BMI\<35 kg/m\^2 * Underwent bariatric surgery or medical therapy * Patients met the diagnostic criteria for MS, defined criteria derived from the joint interim statement (JIS) 2. Exclusion Criteria: * Patients who failed to follow up * Insulin dependent diabetes * congenital dementia * brain trauma * epileps * severe hypoglycemic coma * cerebrovascular disease * ischemic * heart disease * renal dysfunction * alcohol abuse * mental illness * psychoactive substance abuse * unwillingness to provide informed consent
Where this trial is running
Chongqing, Chongqing Municipality
- Stryker Laparoscopy — Chongqing, Chongqing Municipality, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.