Comparing airway management techniques during in-hospital cardiac arrest
Hospital Airway Resuscitation Trial: A Cluster-Randomized, Pragmatic Trial
This study is testing whether using a supraglottic airway or endotracheal intubation during in-hospital cardiac arrest helps patients survive and do better afterwards.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 1060 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Montefiore Medical Center Academic / other |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT05520762 on ClinicalTrials.gov |
What this trial studies
The Hospital Airway Resuscitation Trial (HART) is a cluster-randomized trial that evaluates two advanced airway management strategies during in-hospital cardiac arrest: supraglottic airway placement versus endotracheal intubation. This trial aims to address the limited evidence guiding airway management in this critical setting, where nearly 300,000 patients experience cardiac arrest annually in the U.S. The study will involve adult patients who suffer in-hospital cardiac arrest and require assisted ventilation, comparing outcomes between the two airway management techniques. The goal is to determine which method is more effective in improving patient survival and outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who experience in-hospital cardiac arrest and require assisted ventilation.
Not a fit: Patients who may not benefit from this study include those with existing invasive airways or those with Do Not Resuscitate or Do Not Intubate orders.
Why it matters
Potential benefit: If successful, this study could lead to improved survival rates and outcomes for patients experiencing in-hospital cardiac arrest.
How similar studies have performed: While there is evidence from out-of-hospital settings suggesting supraglottic airways may be as effective as endotracheal intubation, this specific approach in the in-hospital context is novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adult aged \>=18 years 2. Admitted to the hospital for any condition 3. Suffered in-hospital cardiac arrest (loss of pulse and ≥2 minutes of chest compressions) 4. Need for assisted ventilation (defined by initiation of bag-mask-ventilation or other supported ventilation) Exclusion Criteria: 1. Cardiac arrest in the Operating Room or other area not responded to by Critical Care/Emergency Department (ED) teams. 2. Cardiac arrest in which an invasive airway (i.e. endotracheal tube, tracheostomy tube) is already in place 3. Patients with Do Not Resuscitate or Do Not Intubate orders
Where this trial is running
New York, New York
- Montefiore Medical Center — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: Ari Moskowitz, MD — Montefiore Medical Center
- Study coordinator: Ari Moskowitz, MD
- Email: amoskowitz@montefiore.org
- Phone: 718-920-5440
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.