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Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Community-led climate resilience and health integration in District Astore

Official title: Promoting Interventions for Climate Change to Upscale Resilience (PICCTURE) Trial in District Astore

Run by Aga Khan University · NCT07557199 · Data updated 2026-11-12

A cluster randomized trial tests whether community-led adaptation plus primary healthcare–linked activities improve resilience and health outcomes for households in District Astore, Pakistan.

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Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment1350 (estimated)
SponsorAga Khan University
Academic / other
Locations1 site (Karachi, Sindh)
StatusRecruiting
StartedJune 1, 2026
Main results expectedApril 30, 2027
Study endsMay 2027
Registry record updatedOctober 8, 2026
Trial IDNCT07557199 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18 and older who permanently reside in the selected study area and consent to participate.

Probably not a fit

Individuals who relocate during the study period or do not engage with the assigned interventions may not experience measurable benefits.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This three-arm cluster randomized trial in the mountainous District Astore, Gilgit-Baltistan, compares (1) structured community-led adaptation and resilience activities via Village Management Committees, (2) the same approach with added engagement of Lady Health Workers and primary healthcare providers, and (3) a standard control. Clusters are villages or groups of villages, with 30 clusters randomly assigned equally across arms. Households within each cluster are selected to participate. The study aims to determine if these community- and health-linked interventions can enhance household resilience, adaptive capacity, and health-related outcomes in a climate-vulnerable setting. The intervention leverages local governance and health-system linkages to address climate-related hazards such as GLOFs, landslides, and extreme weather, with evaluation focused on resilience and health metrics.

Why it matters

Potential benefit: If successful, the approach could enhance community resilience and health access in climate-vulnerable districts, potentially reducing the health and socioeconomic impacts of environmental shocks.

How similar studies have gone: Previous similar community-based resilience and health-linkage efforts have shown mixed but encouraging signals in improving adaptive capacity and health service uptake in vulnerable populations.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Permanent residents of the selected study area
2. Aged 18 years and above
3. Willing to provide informed consent

Exclusion Criteria:

1- Temporary residents or non-residents of the study are

Where it's running

  • Aga Khan University
    Karachi, Sindh, Pakistan     Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Climate Change 5Disaster Planning 2Aga Khan University 19
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.