Combining Intrathecal Morphine and PENG Block for Pain Relief After Hip Surgery
The Efficacy of Combined Intrathecal Morphine and Pericapsular Nerve Group (PENG) Block on Postoperative Pain and Recovery Quality in Anterior Hip Arthroplasty: A Prospective, Double-blind, Randomized Clinical Trial
This study is testing if using a combination of a nerve block and low-dose morphine can help people feel less pain and recover better after hip surgery compared to using each method on its own.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 3 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Bezmialem Vakif University Academic / other |
| Locations | 1 site (Istanbul, Fatih) |
| Trial ID | NCT06298370 on ClinicalTrials.gov |
What this trial studies
This study compares the effectiveness of combining the Pericapsular Nerve Group (PENG) block with low-dose intrathecal morphine versus using each method alone for managing postoperative pain in patients undergoing hip arthroplasty. The goal is to assess morphine consumption, pain levels, and recovery quality over the first 48 hours after surgery. By utilizing multimodal analgesia, the study aims to reduce opioid use and associated side effects while improving recovery outcomes. The Quality of Recovery (QoR-15) scale will be used to evaluate the overall recovery experience of participants.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 90 undergoing anterior hip arthroplasties with an ASA score of 1 to 4.
Not a fit: Patients with a history of opioid addiction, severe comorbidities, or those unable to provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved pain management and recovery for patients undergoing hip arthroplasty.
How similar studies have performed: Previous studies have shown that combining peripheral nerve blocks with low-dose intrathecal opioids can enhance recovery and reduce opioid consumption, indicating a promising approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged between 18 and 90 years * American Society of Anesthesiologists (score ranging from 1 to 4) * Anterior hip arthroplasties Exclusion Criteria: * Patients with a history of opioid addiction * Individuals under the age of 18 * Those aged 90 and above * Allergies to morphine, fentanyl, bupivacaine, or tramadol * Coagulopathy * Infection at the injection site * Severe cardiac, renal, or hepatic dysfunction * Cases unable to provide informed consent * Body Mass Index \>40 kg/m2 * Known neurological or anatomical deficits in the lower extremities * Patients requiring a transition from spinal anesthesia to general anesthesia
Where this trial is running
Istanbul, Fatih
- Bezmialem Vakif University — Istanbul, Fatih, Turkey (Recruiting)
Study contacts
- Principal investigator: Saadet Oztop, MD — Bezmialem Vakif University
- Study coordinator: Saadet MD Oztop, MD
- Email: soztop@bezmialem.edu.tr
- Phone: +905067861993
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.