Combined quadriceps and calf strengthening to improve gait in knee osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial will enroll 52 adults with grade 2–3 knee osteoarthritis at Hayatabad Medical Complex in Peshawar. Participants will be randomly assigned to receive either the combined quadriceps and calf strengthening program or conventional therapy, and will be assessed over time using gait analysis, strength tests, pain scales, disability indices, functional mobility tests, and sleep quality measures. Data will be analyzed with SPSS using repeated measures ANOVA and mixed-model ANOVA to examine changes between groups. The study aims to determine if adding calf strengthening to quad-focused exercises yields better outcomes than standard care. Safety monitoring and adherence will be ensured throughout the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Both Male and Female
* Participants aged 40-60years.
* Diagnosed with grade 2 and 3 of knee osteoarthritis according to Kellgren-Lawrence
* Quads manual muscle grading \<4
* Ability to understand and comply with exercise instructions.

Exclusion Criteria:

* History of recent knee surgery or trauma in the past six months.
* Inflammatory joint diseases (e.g., rheumatoid arthritis, gout).
* Severe cardiovascular or neurological disorders.
* Uncontrolled hypertension or diabetes.
* Participation in other physiotherapy or pharmacological interventions for knee OA during the study period.
* Cognitive impairment or inability to follow commands

Where it's running

• Hayatabad Medical Complex
  Peshawar, Khyber Pakhtunkhwa, Pakistan Recruiting

Study contacts

• Principal investigator: Aisha Razzaq, PHD — Riphah International University
• Study coordinator: Aisha Razzaq, PHD
• Email: aisha.razzaq@riphah.edu.pk
• Phone: 03015030784

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.