Combined PRP and hyaluronic acid injections for knee osteoarthritis
Official title: Efficacy at One Year of Combined Injections of Plasma Rich in Platelets and Hyaluronic Acid in Knee Osteoarthritis
Run by Centre Hospitalier Universitaire, Amiens · NCT05039463 · Data updated 2026-11-12
This study sees if giving a mix of platelet-rich plasma and hyaluronic acid into the knee helps people with osteoarthritis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens) |
| Status | Recruiting |
| Started | August 16, 2021 |
| Main results expected | June 2026 |
| Study ends | June 2026 |
| Registry record updated | June 15, 2026 |
| Trial ID | NCT05039463 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with knee osteoarthritis who are already receiving or about to receive viscosupplementation or PRP-HA injections at CHU Amiens.
✕Probably not a fit
Patients who do not respond to intra-articular PRP-HA treatment or who have contraindications to injections may not see benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study at CHU Amiens evaluates the real-world use of combined intra-articular injections of platelet-rich plasma (PRP) and hyaluronic acid (HA) for knee osteoarthritis. It aims to observe outcomes after one year of treatment in adults already receiving viscosupplementation or PRP-HA injections. The protocol acknowledges variability in PRP preparation and injection practices and seeks to understand effectiveness across these common clinical approaches. No randomized comparisons are described, focusing on real-world experience and patient responses. Eligibility includes adults undergoing knee OA treatment with PRP-HA or HA alone, with data consent and language considerations noted.
Why it matters
Potential benefit: If successful, patients may experience improved joint symptoms and function from PRP-HA combination injections.
How similar studies have gone: Similar observational work has explored PRP and HA in knee OA with mixed results; this study adds real-world data on combination therapy.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age : \> 18 years old * Patients benefiting, in the context of knee osteoarthritis, from viscosupplementation alone or from two injections of PRP, in combination with HA, at the Amiens University Hospital. Exclusion Criteria: * Patient refusal to use the data * Language barrier * Age less than 18 years old.
Where it's running
-
CHU Amiens
Amiens, France Recruiting
Study contacts
- Study coordinator: Laure Le Monnier, Md
- Email: lemonnier.laure@chu-amiens.fr
- Phone: 03 22 66 82 50
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.