Clinical trial Recruiting at 1 site Observational Ages 18 and up

Combined PRP and hyaluronic acid injections for knee osteoarthritis

Official title: Efficacy at One Year of Combined Injections of Plasma Rich in Platelets and Hyaluronic Acid in Knee Osteoarthritis

Run by Centre Hospitalier Universitaire, Amiens · NCT05039463 · Data updated 2026-11-12

This study sees if giving a mix of platelet-rich plasma and hyaluronic acid into the knee helps people with osteoarthritis.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorCentre Hospitalier Universitaire, Amiens
Academic / other
Locations1 site (Amiens)
StatusRecruiting
StartedAugust 16, 2021
Main results expectedJune 2026
Study endsJune 2026
Registry record updatedJune 15, 2026
Trial IDNCT05039463 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with knee osteoarthritis who are already receiving or about to receive viscosupplementation or PRP-HA injections at CHU Amiens.

Probably not a fit

Patients who do not respond to intra-articular PRP-HA treatment or who have contraindications to injections may not see benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study at CHU Amiens evaluates the real-world use of combined intra-articular injections of platelet-rich plasma (PRP) and hyaluronic acid (HA) for knee osteoarthritis. It aims to observe outcomes after one year of treatment in adults already receiving viscosupplementation or PRP-HA injections. The protocol acknowledges variability in PRP preparation and injection practices and seeks to understand effectiveness across these common clinical approaches. No randomized comparisons are described, focusing on real-world experience and patient responses. Eligibility includes adults undergoing knee OA treatment with PRP-HA or HA alone, with data consent and language considerations noted.

Why it matters

Potential benefit: If successful, patients may experience improved joint symptoms and function from PRP-HA combination injections.

How similar studies have gone: Similar observational work has explored PRP and HA in knee OA with mixed results; this study adds real-world data on combination therapy.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* age : \> 18 years old
* Patients benefiting, in the context of knee osteoarthritis, from viscosupplementation alone or from two injections of PRP, in combination with HA, at the Amiens University Hospital.

Exclusion Criteria:

* Patient refusal to use the data
* Language barrier
* Age less than 18 years old.

Where it's running

  • CHU Amiens
    Amiens, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.