Hyaluronic acid injections to reduce knee inflammation and improve symptoms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 45–75 with Kellgren‑Lawrence stage 2–3 knee osteoarthritis and at least three months of pain despite conservative treatment will be enrolled. Participants receive intra‑articular hyaluronic acid injections or a saline placebo and pre‑ and post‑treatment TNF‑alpha and IL‑1β levels will be measured in blood and synovial fluid, along with DNA methylation changes. Patient‑reported pain, functional status, and quality of life will be recorded and correlated with biomarker changes. The trial is conducted at Istanbul University Faculty of Medicine and funded by the Istanbul University Research Fund.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of knee osteoarthritis according to ACR (American College of Rheumatology) criteria
* Knee pain for more than 3 months
* Presence of knee pain resistant to conservative treatment for at least 3 months
* To be between the ages of 45-75
* Kellgren-Lawrence stage 2-3 gonarthrosis detected in the available knee direct radiographs of the patients

Exclusion Criteria:

* Patients with KL stage 1 and 4 OA
* Systematic diseases (severe cardiovascular disease, severe renal failure, severe hepatic failure, uncontrolled diabetes, cancer, immunosuppression, haematological diseases, systemic bone diseases)
* Bleeding tendency (acquired or inherited) \[lNR\>2 in a patient on Coumadin\],
* Infection (systemic or local)
* Secondary knee osteoarthritis (inflammatory joint disease, post-traumatic, post-infectious, etc.)
* Major knee trauma within the last 1 year
* BMI \>40
* History of total knee or hip arthroplasty within 1 year
* Pregnancy
* History of intra-articular injection within the last 6 months
* Patients with Hb less than 11 g/dl and Plt less than 150.000
* Presence of allergy to hyaluronic acid products

Where it's running

• Istanbul University, Istanbul Faculty of Medicine
  Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Dicle Rotinda Özdaş Sevgin
• Email: rotindaozdas95@gmail.com
• Phone: +90 530-141-5940

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.