Botulinum toxin vs hyaluronic acid injections for knee osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares two intra-articular injections—botulinum toxin type A and hyaluronic acid—in adults with knee osteoarthritis. Participants are 50 years or older and meet diagnostic criteria with moderate radiographic OA. The trial will assess pain outcomes after treatment to determine which injection offers more pain relief with an acceptable safety profile. The mechanism involves botulinum toxin reducing nerve signaling and hyaluronic acid aiming to improve joint lubrication, with patients followed for a defined period to evaluate efficacy and safety. The study is conducted at Tanta University in Egypt under a lead sponsorship with no listed collaborators.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 50 years.
* Both genders.
* Chronic knee osteoarthritis (KOA) according to American College of Rheumatology criteria for the diagnosis of knee osteoarthritis.
* Third or fourth grade Kellgren and Lawrence system for classification of osteoarthritis based on radiological data, it is a common method of classifying the severity of osteoarthritis (OA) using five grades according to the following sites and projections.

Exclusion Criteria:

* History of intra-articular injection within the last 6 months,
* History of surgery on the knee joint or major trauma to the lower limb causing fracture.
* Body mass index (BMI) more than 40 kg/m2.
* Medical conditions affecting the joint or lower extremity function such as severe osteoporosis, rheumatoid arthritis, collagen vascular diseases, and gout.
* Diabetic patient.
* Any contraindication to intra-articular injections for instance immunodeficiency, coagulation defect or anticoagulation therapy taking or skin infection at the site of injection.
* Hypersensitivity to Botulinum toxin or hyaluronic acid.

Where it's running

• Tanta University
  Tanta, El-Gharbia, Egypt Recruiting

Study contacts

• Study coordinator: Mohammed S ElSharkawy, MD
• Email: mselsharkawy@med.tanta.edu.eg
• Phone: 00201148207870

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.