Cognitive remediation for working memory after head injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a small, nonrandomized design using a multiple baseline single-case approach across three patients and two outcomes: working memory performance and use of compensatory strategies. Participants undergo a four-phase remediation program over 12 weeks with twice-weekly, one-on-one sessions, including therapeutic education and targeted cognitive tasks, with intermittent tDCS during the second phase. The baseline duration is randomized, and neuropsychological assessments are repeated after phases C and D to measure changes. Inclusion requires moderate to severe head trauma with documented working memory complaints; several neuropsychological criteria are used to confirm impairment. Exclusion includes significant language or sensory deficits that would impede testing.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Moderate or severe head trauma, defined by an initial Glasgow score ≤ 12/15, duration of post-traumatic amnesia superior to 24 hours and/or the presence of abnormalities on brain imaging,
* Moderate or severe head trauma occurring within a period greater than or equal to 3 months,
* Working memory complaints assessed by the Working Memory Questionnaire,
* Patients with a working memory disorder in at least one of the following tests: Digit Memory subtest WAIS-IV (standard deviation ≤ -2) , PASAT (percentile ≤ 10), Brown-Peterson (standard deviation ≤ -2).

Exclusion Criteria:

* Presence of aphasia, apraxia or severe neglect demonstrated by standardized neuropsychological tests during the inclusion visit: language - oral naming of BECS-GRECO images, ideational praxis and ideomotor , neglect - bell test,
* Insufficient visual or auditory abilities and oral and written expression to carry out neuropsychological tests,
* Severe depression assessed by the Beck Depression Inventory (BDI)
* Chronic alcoholic poisoning, drug addiction,
* Progressive general illness,
* Progressive psychiatric or neurological condition leading to cognitive impairment,
* Hospitalization for a neurological pathology since the acute phase of the qualifying event,
* Patient requiring surgery during study participation.
* Pregnant or breastfeeding women

Where it's running

• UH Toulouse
  Toulouse, France Recruiting

Study contacts

• Principal investigator: Adeline Julien — University Hospital, Toulouse
• Study coordinator: Adeline Julien
• Email: julien.ade@chu-toulouse.fr
• Phone: 05 61 77 97 21

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.