Cognitive rehabilitation for long COVID brain fog
Technique to Enable Return-to-Work by Employees With Long COVID Brain Fog
This study is testing two different brain training methods to see which one helps adults with long COVID brain fog improve their thinking skills and daily activities.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Alabama at Birmingham Academic / other |
| Locations | 1 site (Birmingham, Alabama) |
| Trial ID | NCT06095297 on ClinicalTrials.gov |
What this trial studies
This study compares two cognitive rehabilitation approaches for adults experiencing mild to moderate cognitive impairment due to long COVID. One approach focuses on processing speed training and everyday cognitive tasks, while the other emphasizes reaction time and lifestyle changes. Both methods include non-invasive vagus nerve stimulation and aim to improve cognitive function and daily living activities. Participants will engage in web-based games and in-lab training to enhance their cognitive abilities and overall brain health.
Who should consider this trial
Good fit: Ideal candidates are adults over three months post-COVID with mild cognitive impairment and brain fog affecting daily activities.
Not a fit: Patients with cognitive impairment due to developmental disabilities, psychiatric disorders, or other neurological conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly improve cognitive function and quality of life for patients suffering from long COVID brain fog.
How similar studies have performed: Other studies have shown promise in cognitive rehabilitation for similar conditions, but this specific approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>3 months post COVID * mild or greater cognitive impairment * moderate or greater brain fog * impairment in performance of daily activities * reside in community * reliable transportation to lab * sufficiently mentally and physically fit * adequate sight and hearing * ability to follow directions, and retain information * sufficient English proficiency Exclusion Criteria: * cognitive impairment due to developmental disability, psychiatric disorder, or substance abuse, TBI or progressive brain disease * stroke prior to the onset of COVID * current substance abuse disorder * prior cognitive processing speed training on DoubleDecision or similar program * cannot tolerate trans-auricular vagus nerve stimulation
Where this trial is running
Birmingham, Alabama
- University of Alabama at Birmingham — Birmingham, Alabama, United States (Recruiting)
Study contacts
- Principal investigator: Gitendra Uswatte, PhD — Professor of Psychology, University of Alabama at Birmingham
- Study coordinator: Madeline Rathz, BS
- Email: mgrathz@uab.edu
- Phone: 205-934-9768
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.