Coeliac Plexus vs Splanchnic Nerve Neurolysis for Upper Abdominal Cancer Pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with upper abdominal malignancies and significant pain are randomly assigned to receive either a neurolytic coeliac plexus block or a neurolytic splanchnic nerve block under fluoroscopic guidance. Pain and safety are tracked immediately after the procedure and at 7 days, 1 month, and 3 months, with quality of life also evaluated at baseline. The trial aims to compare pain relief and adverse effects between the two nerve-block approaches. Procedures involve image-guided needle placement and neurolytic alcohol injections, with standard pre-procedure labs and post-procedure monitoring. The study is conducted at Bangladesh Medical University in Dhaka.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patient
* Both genders
* Diagnosed case of upper abdominal malignancy (pancreatic, gastric, hepatic, or biliary origin)
* Experiencing moderate to severe pain (≥5 on a 10 point visual analog scale)
* Patients who are conscious and can communicate
* No Contraindication for nerve block (e.g., coagulopathy, anticoagulant drugs)

Exclusion Criteria:

* Previous coeliac plexus block, splanchnic nerve block, or major abdominal nerve ablation
* Severe spinal deformities or anatomical distortion at the coeliac plexus or splanchnic nerve site
* Local or systemic infection at or near the block site
* Known allergy to local anesthetics or neurolytic agents
* Pregnancy
* Lactating mother
* Cognitive impairment or psychiatric illness

Where it's running

• Bangladesh Medical University
  Dhaka, Bangladesh Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.