Bilateral ESP Block vs EOIP Block After Liver Resection
Official title: Comparative Effects of Erector Spinae Plane Block and External Oblique Intercostal Plane Block on Postoperative Respiratory Recovery Following Liver Resection: A Randomized Controlled Trial
Run by Menoufia University · NCT07740382 · Data updated 2026-11-12
This study tests whether a bilateral erector spinae plane (ESP) block provides better postoperative breathing and pain relief than a bilateral EOIP block after liver surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 116 (estimated) |
| Sponsor | Menoufia University Academic / other |
| Locations | 1 site (Alexandria, Sbein-Elkom) |
| Status | Recruiting |
| Started | September 2026 |
| Main results expected | January 1, 2027 |
| Study ends | January 1, 2027 |
| Registry record updated | October 6, 2026 |
| Trial ID | NCT07740382 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–75 years old with ASA I–III status scheduled for elective hepatic upper abdominal surgery, able to provide informed consent and understand the NRS.
✕Probably not a fit
Patients with contraindications to fascial plane blocks, severe pulmonary failure on home oxygen, or other exclusion criteria may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults undergoing elective liver resection via upper abdominal incisions are randomized to receive either ultrasound-guided bilateral ESP block or bilateral EOIP block. The trial uses multiple respiratory and analgesia measures to evaluate recovery, including diaphragmatic motion, lung ultrasound, oxygen needs, and postoperative pulmonary complications. The investigators hypothesize that the ESP block will improve respiratory function after surgery, partially through better pain control. The study is sponsored by Menoufia University with collaboration from the National Liver Institute, Egypt, and will be conducted at Menoufia University and affiliated sites. It excludes patients with contraindications to fascial plane blocks, significant comorbidities, or those needing planned postoperative ventilation.
Why it matters
Potential benefit: If successful, patients may experience better breathing and less pain after liver surgery, potentially speeding recovery.
How similar studies have gone: Previous work in regional anesthesia for abdominal surgery has shown analgesic benefits with fascial plane blocks; the specific ESP vs EOIP comparison is less established and could be pioneering.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients aged 18-75 years * Adult with American Society of Anesthesiologists (ASA) physical status I-III * Scheduled for elective hepatic surgery via upper abdominal incisions will be eligible. * All participants will be required to understand the Numeric Rating Scale (NRS) and provide informed consent. Exclusion Criteria: * Patient refusal * Coagulopathy (INR\>1.4 or platelet count\<8 x 104) * Contraindications to fascial plane blocks * Infection at the puncture site * Known allergy to study medications * Chronic opioid use or chronic pain syndromes * Severe chronic respiratory failure requiring home oxygen or noninvasive ventilation * Pregnancy * Body mass index\>40 kg/m² * When ultrasound imaging will be deemed unreliable * Emergency surgery * Hemodynamic instability * Reoperation during the same hospital admission. * Patients scheduled preoperatively for elective postoperative mechanical ventilation or planned ICU intubation.
Where it's running
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National Liver Institute, Menoufia University
Alexandria, Sbein-Elkom, Egypt Recruiting
Study contacts
- Study coordinator: Nevine Mostafa Soliman
- Email: nevinemostafa@gmail.com
- Phone: 01128861471
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.