CO2 flushing before TEVAR to lower brain embolisms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

FlushTEVAR is a multicenter, randomized, single-blind interventional study led by the University of Bologna. It compares a pre-implant CO2 endograft flushing sequence followed by saline flushing against standard flushing during thoracic endovascular aortic repair. The goal is to see whether this CO2 technique lowers periprocedural embolic events and cerebral infarctions. Eligible patients include adults with type B acute aortic syndrome or specific Crawford-classified aneurysms. The trial is coordinated across several Italian centers and aligns with a non-profit research model.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age is at least 18 years
* Present with type B acute aortic syndrome in the acute, subacute, or chronic phase
* Thoracic and thoracoabdominal aneurysms with Crawford extent I, II, III, or IV
* Written informed consent

Exclusion Criteria:

* Procedure performed using CO₂ angiography
* Endografts without a sheath is used
* Emergency endovascular treatment required
* Patient has experienced a stroke or TIA within the previous six months
* Proximal sealing zone is 0 or 1
* Any contraindication to DW-MRI
* Pregnancy or breastfeeding

Where it's running

• IRCCS Azienda Ospedaliero-Universitaria di Bologna
  Bologna, Italy, Italy Recruiting
• A.S.S.T. Spedali Civili di Brescia
  Brescia, Italy, Italy Not yet recruiting
• IRCCS Policlinico San Martino di Genova
  Genova, Italy, Italy Not yet recruiting
• Azienda Ospedaliero-Universitaria di Padova
  Padova, Italy, Italy Not yet recruiting

Study contacts

• Principal investigator: Mauro Gargiulo, MD — University of Bologna
• Study coordinator: Mauro Gargiulo, MD
• Email: mauro.gargiulo2@unibo.it
• Phone: 0512144252

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Thermosensitive Gel With Octenidine as an Adjunct to Standard Periodontal Cleaning

  This study tests whether PX-Gel, a thermosensitive hyaluronic acid-octenidine gel, added to scaling and root planing helps healing periodontal pockets in adults with periodontitis.

  Recruiting at 2 sites University of Bologna · Bologna, BO and 1 other locations · NCT07725913

• Italian YOLO: a web-based ACT program to boost student wellbeing

  A web-based ACT program called Italian YOLO is tested to see if it improves psychological wellbeing and reduces distress among university students.

  Recruiting University of Bologna · Bologna, BO · NCT07654569

• Sustainable and inclusive alternative proteins for Mediterranean diets (CIPROMED)

  This study tests whether breads and other Mediterranean foods made with alternative proteins (like cricket, spirulina, hemp, and legumes) change appetite, fullness, food choices, and metabolic markers in healthy adults and people who are overweight.

  Recruiting University of Bologna · Bologna, BO · NCT07553936

• Neck (internal jugular) ultrasound to check fluid levels in people on haemodialysis

  This project will test whether a quick ultrasound of the internal jugular vein can tell if people on chronic haemodialysis have too much or too little fluid.

  Recruiting University of Bologna · Bologna · NCT07438613

• Oral signs to help spot eating disorders early

  This project will test whether a standardized checklist of mouth and dental signs can help detect eating disorders in adults aged 18–40 during routine dental visits.

  Recruiting University of Bologna · Bologna · NCT07295197

• Functional low‑GI versus standard wholegrain carbohydrates for adults with moderately high triglycerides

  This study will test whether swapping standard wholegrain carbs for functional low‑GI bakery foods within a Mediterranean diet helps improve the triglyceride‑glucose index and vascular stress markers in adults with suboptimal triglyceride levels.

  Recruiting University of Bologna · Bologna, BO · NCT07198789

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.