Chronic Cough and Airway Remodelling in Refractory Cough Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will enroll up to 40 non-smoking adults with chronic cough lasting at least 12 months who are undergoing bronchoscopy for clinical indications. Researchers will analyze blood and bronchoalveolar lavage fluid for injury mediators, and use chest CT scans and bronchial tissue samples to assess airway remodelling and epithelial injury. The goal is to explore how cough duration and severity relate to inflammation, airway damage, and structural changes. Participants will undergo chest CT and bronchoscopy as part of standard clinical care, with data collected to characterize airway pathology associated with refractory cough.

Why it matters

Who can join: the full rules

Inclusion criteria for the study group:

1. age between 18 and 75 years,
2. chronic cough of at least one year duration, with no previous treatment (at least 2 previous unsuccessful attempts at pharmacological treatment of cough)
3. negative history of smoking (at least 6 months of abstinence),
4. negative history of treatment with angiotensin-converting enzyme inhibitors (ACEI),
5. normal chest radiograph or with changes not relevant to cough formation,
6. no respiratory tract infections in the past 6 weeks,
7. written consent from the patient to participate in the study.

Exclusion Criteria:

1. patients less than 18 and more than 75 years of age,
2. cough lasting less than 12 months,
3. active smoking or abstinence period of less than 6 months,
4. respiratory tract infection 6 weeks prior to inclusion or at the time of study conduct - retry inclusion after 6 weeks,
5. cancer or interstitial lung disease,
6. contraindications to functional testing, sputum induction or bronchoscopy

Where it's running

• Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw
  Warsaw, Masovian Voivodeship, Poland Recruiting
• Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw
  Warsaw, Warsaw, Poland Recruiting
• Medical University of Warsaw
  Warsaw, Poland Recruiting
• Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw
  Warsaw, Poland Recruiting

Study contacts

• Study coordinator: Marta Dabrowska, MD, PhD
• Email: mdabrowska@mp.pl
• Phone: +48 501157765

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.