Evaluating treatment satisfaction with gefapixant for chronic cough

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess treatment satisfaction in patients with refractory chronic cough (RCC) who are treated with gefapixant, a P2X3 receptor antagonist. It will explore the relationship between taste disturbances, a common side effect of gefapixant, and improvements in cough-specific quality of life (QoL). The study will involve adult patients who have not responded to standard treatments for chronic cough and will evaluate their experiences in a real-world clinical setting. The hypothesis is that taste disturbance may correlate with enhanced treatment satisfaction and cough-specific QoL.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult patients with RCC and UCC (8 weeks or more).
2. Cough is refractory to intensive specific treatments for causes of chronic cough.
3. Never smokers and ex-smokers with having smoking history of ≤20 pack-years.

Exclusion Criteria:

1. Patients with lung cancer, interstitial lung diseases, bronchiectasis, or respiratory infection such as tuberculosis and acute pneumonia.
2. Current smoker, ex-smokers with having smoking history of \>20 pack-years, or those who quit smoking within six months prior to receiving gefapixant.
3. Those who are pregnant.

Where it's running

• Nagoya City University Hospital
  Nagoya, Aichi-ken, Japan Recruiting
• Nagoya City University
  Nagoya, Aichi-ken, Japan Not yet recruiting

Study contacts

• Principal investigator: Yoshihiro Kanemitsu — Nagoya City University Graduate School of Medical Sciences and Medical School
• Study coordinator: Yoshihiro Kanemitsu, MD, PhD
• Email: kaney32@med.nagoya-cu.ac.jp
• Phone: +81-52-853-8216

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.