Chromium Picolinate for Appetite and Cravings in Overweight Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This open-label, decentralized pilot study uses a home-based approach to assess the effects of 8 mg daily chromium picolinate on appetite and food cravings. Participants will complete validated questionnaires, wear continuous glucose monitoring, maintain daily meal logs, and answer weekly safety surveys via a smartphone app. The study stratifies participants by prior exposure to GLP-1 receptor agonists and follows 110 evaluable adults aged 35–70 with BMI 25–31, enrolled remotely. Outcomes include changes in FCQ-T scores, RAID-FN food noise, appetite VAS metrics, glycemic variability, body weight, and safety. Data collected will inform potential benefits and feasibility of at-home chromium supplementation for appetite management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Males/Females age 35-70 years old, inclusive
* Self-reported BMI between 25-31 kg/m²
* In good general health at the time of screening (Investigator discretion, applied against the objective screening data and the exclusion criteria below - i.e., confirmation that no significant, unlisted comorbidity or acute condition is present that would confound assessment of appetite/craving outcomes or compliance), defined as medically stable for at least the last 6 months.
* Self-reported weight stable, defined as body weight has not fluctuated significantly over the last 3 months. "Significantly" is defined as a change of more than 3% to 5% of total body weight, or a shift over 5 lbs (Pagidipati 2021) Moderate food cravings, defined as a score 25-54 on the Food Cravings Questionnaire -Reduced (FCQ-15)
* Able to read and understand English.
* Able to read, understand, and provide informed consent.
* Able to use a personal smartphone device and download the Chloe app by People Science.
* Able to receive shipment of the product and supplies at an address within the United States.
* Able to complete study assessments over the course of up to 15 weeks.

Exclusion Criteria:

* Participants actively engaged in weight loss programs or actively dieting.
* Participants taking any supplements (i.e. fat burners, etc.) specifically for weight loss/management (including appetite control)
* Participants taking any cinnamon, berberine, or chromium containing supplements.
* Do not have a personal smartphone, internet access, or unwilling to download Chloe.
* Current or prior use of a GLP-1 within the last 2 weeks
* Concomitant Therapies:

Participants receiving any investigational therapies or treatments within 30 days prior to consent.

* Other Illnesses or Conditions: Participants who have the following comorbidities or gastrointestinal illnesses are excluded:
* Currently diagnosed with Alcohol Use Disorder and/or Substance Use Disorder
* Currently diagnosed with an Eating Disorder
* Currently pregnant, planning to become pregnant in the next 3 months, or breastfeeding
* Any underlying medical conditions or comorbidities that may confound the assessment of digestive symptoms or the evaluation of the study outcomes.
* Have a significant illness, disease or condition which, in the opinion of the principal investigator, may impact their ability to participate in the study or impact the study outcomes.
* Known hypersensitivity or previous allergic reaction to chromium containing products.
* Are unlikely for any reason to be able to comply with the trial or considered unsuited for participation in the study by the Principal Investigator.

Where it's running

• People Science
  Los Angeles, California, United States Recruiting

Study contacts

• Principal investigator: Noah Craft, MD — People Science, Inc.
• Study coordinator: Megha Doshi, MD
• Email: megha@peoplescience.health
• Phone: 5626736744

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.