Short-term effects of ultra-processed foods on metabolism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized 2×2 factorial four-way crossover feeding study enrolling 24 men and women at the University of Gothenburg. Participants will receive four supervised breakfasts that vary by ultra-processed food content (high vs low) and by energy density (high vs low), with each condition crossed over. Blood samples and continuous appetite measures will be collected up to four hours after each breakfast, followed by an ad libitum lunch where energy intake is recorded. The design isolates the short-term effects of UPF and energy density on postprandial metabolism, hunger, and calorie intake.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Body mass index (BMI) 18.5-30 kg/m2
* Fasting glucose \< 6.1 mmol/l
* Hb \>110 g/L
* Weight stability the last 3 months +/-5%

Exclusion Criteria:

* Food allergies, intolerances or preferences preventing consumption of any products included in the study.
* Unable to sufficiently understand written and spoken Swedish or English to provide written consent and understand information and instructions from the study personal.
* Pregnant, lactating or planning a pregnancy during the study period.
* Blood donation or participation in a clinical study with blood sampling within 30 days prior to screening visit and throughout the study.
* History of gastrointestinal conditions or major gastrointestinal surgery (Inflammatory bowel disease, Crohn's disease, malabsorption, colostomy, bowel resection, gastric bypass surgery etc.).
* Type 1 diabetes or type 2 diabetes.
* Thyroid disorder.
* Current smoking, vaping.
* Following any weight reduction program or having followed one during the last 6 months prior to screening.
* Not habitually eating breakfast (\<5 times/week).
* Restrained eating based on the three-factor eating questionnaire.

Where it's running

• Department of internal medicine and clinical nutrition, University olf Gothenburg
  Gothenburg, Sweden Recruiting

Study contacts

• Principal investigator: Therese Karlsson, PhD — University of Gothenburg, Institute of medicine
• Study coordinator: Therese Karlsson, PhD
• Email: therese.karlsson@gu.se
• Phone: +46704089150

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.