Vitamin D treatment after intracerebral hemorrhage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, randomized, open-label, blinded-endpoint (PROBE) pilot comparing vitamin D supplementation versus standard care in adults with spontaneous supratentorial intracerebral hemorrhage. Participants are randomized 1:1 to receive vitamin D 4000 IU daily for two weeks then 1000 IU daily for 24 weeks, or standard care, with neuroradiologists blinded for hematoma measurements. The primary outcomes are the rate of hematoma resolution at 14 days and the incidence of hypercalcemia and vitamin D toxicity; hematoma volume change is centrally read by a blinded rater. Key eligibility includes age ≥18, presentation within 96 hours of ICH, premorbid mRS ≤2, and ICH volume ≥2 mL, while patients with severe organ dysfunction, hypercalcemia, or anticipated surgical evacuation are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Spontaneous ICH diagnosis
* Age ≥ 18 years
* Within 96 hours of ICH
* Premorbid Modified Rankin Scale of ≤2
* Supratentorial ICH
* ICH volume ≥2 mL

Exclusion Criteria:

* Expected life expectancy of \<1 year
* Glasgow Coma Scale \<9
* Anticipated surgical evacuation of hematoma
* Inability to participate in follow-up activity
* Hypercalcemia
* Hyperphosphatemia
* History of kidney stones
* Bleeding tendency
* Severe renal impairment
* Severe liver impairment
* Known contraindication or allergy to vitamin D

Where it's running

• The University of Hong Kong
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Kay Cheong Teo, MBBS, MD — The University of Hong Kong
• Study coordinator: Kay Cheong Teo, MBBS, MD
• Email: kcteo@hku.hk
• Phone: 852-22552368

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.