China Axial Length Reference
Axial Length Study of Children and Adolescents in Ten Provinces of China
This project will measure axial length in 30,000 Chinese children aged 3 to 18 over three years to create age-specific reference ranges.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30000 (estimated) |
| Ages | 3 Years to 18 Years |
| Sex | All |
| Sponsor | Shanghai Eye Disease Prevention and Treatment Center Academic / other |
| Locations | 2 sites (Shanghai, Shanghai Municipality and 1 other locations) |
| Trial ID | NCT05770661 on ClinicalTrials.gov |
What this trial studies
This is a multicenter, observational cohort of 30,000 children and adolescents in China with baseline cycloplegic eye measurements and annual visits for three years. Investigators will collect axial length and related ocular parameters to map growth trajectories by age. Participants are recruited from several hospitals and must have lived in the study area for at least one year and remain locally available for two more years. The main goal is to produce normative axial length reference ranges to inform clinical care and public health approaches to myopia in Chinese youth.
Who should consider this trial
Good fit: Ideal candidates are children aged 3 to 18 who have lived in the study area for at least one year, can cooperate with eye exams, and whose parents or guardians provide consent.
Not a fit: Children with significant mental or ophthalmic diseases that prevent reliable eye assessment, those unable to cooperate, or those planning to move away within two years are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, clinicians and public health programs will have robust, age-specific axial length norms to better predict myopia risk and guide monitoring or interventions for Chinese children.
How similar studies have performed: Previous population-based axial length and myopia growth studies have informed care, but this large multicenter, three-year Chinese cohort is comparatively larger and more regionally focused.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 3 to 18 years * Have been lived in the research areas for at least one year, and will not move to other places in the following two years * Parents or guardians sign an informed consent form, and children over 6 years old need oral consent to participate Exclusion Criteria: * Mental diseases, unable to cooperate to complete the eye assessment * Ophthalmic diseases, inability to cooperate to complete the inspection
Where this trial is running
Shanghai, Shanghai Municipality and 1 other locations
- Shanghai Eye Disease Prevention & Treatment Center — Shanghai, Shanghai Municipality, China (Recruiting)
- Shanghai Eye Disease Prevention and Treatment Center — Shanghai, China (Recruiting)
Study contacts
- Study coordinator: Xun Xu, MD
- Email: drxuxun@sjtu.edu.cn
- Phone: 021-53555032
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.