Characterizing lung interstitial and airway diseases to improve diagnosis and care

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will start with a large retrospective review from 9 hospitals covering about 10,000 cases to describe how ILD and airway diseases co-occur and relate to other lung conditions. They will develop classification and diagnostic criteria based on these findings. Next, a prospective, disease-specific cohort of about 900 patients will be followed for up to 2 years to observe prognosis, identify prognostic factors, and assess comorbidity severity. The study will also examine current treatments and associated medical costs through cost-effectiveness analyses over a total 4-year period (2024–2028).

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. age between 40-80 years old;
2. inpatients with an admission diagnosis of COPD, Idiopathic pulmonary fibrosis, nonspecific interstitial pneumonia, patients with the following diagnoses were screened by chest CT (slice thickness ≤1.5 mm) during hospitalization and by in-hospital or prior pulmonary function;
3. Inpatients who meet the criteria can complete pulmonary function tests and chest HRCT examinations within one month before expected discharge (excluding hospitalized patients with stable interstitial lung disease or airway disorders);
4. among outpatients, patients with chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, nonspecific interstitial pneumonia, COPD with pulmonary interstitial abnormalities, idiopathic pulmonary fibrosis with airway lesions, nonspecific interstitial pneumonia with airway lesions, pulmonary fibrosis with emphysema syndrome were diagnosed through chest CT (layer thickness ≤1.5mm) and lung function;
5. provide informed consent.

Exclusion Criteria:

1. expected survival less than 12 months;
2. planned lung transplantation or pneumonectomy within 12 months;
3. pregnant or lactating women;
4. Has previously undergone lobectomy or received thoracic radiotherapy.

Where it's running

• Xiangya Hospital
  Changsha, Hunan, China Recruiting

Study contacts

• Study coordinator: Ruoxi He, MD
• Email: heruoxi@csu.edu.cn
• Phone: 86+18874167666

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.