Characterising neuromuscular function after stroke
Official title: Characterising the Neuromuscular Function of Stroke Patients During Recovery
Run by University of Nottingham · NCT07013188 · Data updated 2026-11-12
This project will test how stroke affects muscle and nerve control in adults aged 40–85 who had a stroke in the last five years and still have one-sided limb weakness.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 40 Years to 85 Years |
| Sex | All |
| Enrollment | 16 (estimated) |
| Sponsor | University of Nottingham Academic / other |
| Locations | 1 site (Derby, Derbyshire) |
| Status | Recruiting |
| Started | June 1, 2024 |
| Main results expected | October 1, 2025 |
| Study ends | May 1, 2026 |
| Registry record updated | June 10, 2025 |
| Trial ID | NCT07013188 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 40–85 with a confirmed stroke in the last five years who can give informed consent and report ongoing one-sided limb weakness are ideal candidates.
✕Probably not a fit
People with dementia or significant cognitive impairment, recent malignancy, serious uncontrolled cardiac or respiratory disease, dialysis dependence, recent steroid/hormone therapy, significant musculoskeletal disorders, or who are wheelchair-dependent are excluded and unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a pilot observational project recruiting adults aged 40–85 with a confirmed stroke within the past five years who report persistent unilateral limb impairment. Participants will attend the Royal Derby Hospital/University of Nottingham site for detailed neuromuscular assessments, including clinical exams and measurements of muscle activation and function. No experimental therapies are given; collected data will be used to map common patterns of motor deficit. The findings are intended to inform the design of targeted rehabilitation approaches such as constraint-induced movement therapy, functional electrical stimulation, or virtual-reality rehabilitation.
Why it matters
Potential benefit: If successful, the findings could help clinicians tailor rehabilitation therapies to improve arm and leg function after stroke.
How similar studies have gone: Related work shows that targeted rehab methods (CIMT, FES, VR) can improve function, but detailed neuromuscular characterisation specifically in this post-stroke group is still limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * • Aged between 40-85 years * Willing and able to give informed consent for participation in the study * Had a confirmed stroke within the last 5 years * Self-reports persisting post-stroke loss of unilateral limb function Exclusion Criteria: * • Diagnosis of cognitive impairment/dementia * Current or recent (\<2y) malignancy * Severe respiratory disease (e.g., uncontrolled asthma, COPD, pulmonary hypertension) * Active cardiovascular disease: Uncontrolled hypertension (BP\>160/100mmHg); Recent (\<12mo) cardiac event; Heart failure (Class III/IV); Significant arrhythmia; Unstable angina * Metabolic disease: Untreated hyper/hypoparathyroidism; Cushing's disease * Significant musculoskeletal disorders (based on clinical opinion) * Dialysis patients * Recent steroid treatment within 6 months or hormone replacement therapy * Mobility dependant (wheelchair dependency)
Where it's running
-
Royal Derby Hospital branch, School of Medicine, University of Nottingham
Derby, Derbyshire, United Kingdom Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.