Characterising neuromuscular function after stroke
Characterising the Neuromuscular Function of Stroke Patients During Recovery
This project will test how stroke affects muscle and nerve control in adults aged 40–85 who had a stroke in the last five years and still have one-sided limb weakness.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 16 (estimated) |
| Ages | 40 Years to 85 Years |
| Sex | All |
| Sponsor | University of Nottingham Academic / other |
| Locations | 1 site (Derby, Derbyshire) |
| Trial ID | NCT07013188 on ClinicalTrials.gov |
What this trial studies
This is a pilot observational project recruiting adults aged 40–85 with a confirmed stroke within the past five years who report persistent unilateral limb impairment. Participants will attend the Royal Derby Hospital/University of Nottingham site for detailed neuromuscular assessments, including clinical exams and measurements of muscle activation and function. No experimental therapies are given; collected data will be used to map common patterns of motor deficit. The findings are intended to inform the design of targeted rehabilitation approaches such as constraint-induced movement therapy, functional electrical stimulation, or virtual-reality rehabilitation.
Who should consider this trial
Good fit: Adults aged 40–85 with a confirmed stroke in the last five years who can give informed consent and report ongoing one-sided limb weakness are ideal candidates.
Not a fit: People with dementia or significant cognitive impairment, recent malignancy, serious uncontrolled cardiac or respiratory disease, dialysis dependence, recent steroid/hormone therapy, significant musculoskeletal disorders, or who are wheelchair-dependent are excluded and unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the findings could help clinicians tailor rehabilitation therapies to improve arm and leg function after stroke.
How similar studies have performed: Related work shows that targeted rehab methods (CIMT, FES, VR) can improve function, but detailed neuromuscular characterisation specifically in this post-stroke group is still limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * • Aged between 40-85 years * Willing and able to give informed consent for participation in the study * Had a confirmed stroke within the last 5 years * Self-reports persisting post-stroke loss of unilateral limb function Exclusion Criteria: * • Diagnosis of cognitive impairment/dementia * Current or recent (\<2y) malignancy * Severe respiratory disease (e.g., uncontrolled asthma, COPD, pulmonary hypertension) * Active cardiovascular disease: Uncontrolled hypertension (BP\>160/100mmHg); Recent (\<12mo) cardiac event; Heart failure (Class III/IV); Significant arrhythmia; Unstable angina * Metabolic disease: Untreated hyper/hypoparathyroidism; Cushing's disease * Significant musculoskeletal disorders (based on clinical opinion) * Dialysis patients * Recent steroid treatment within 6 months or hormone replacement therapy * Mobility dependant (wheelchair dependency)
Where this trial is running
Derby, Derbyshire
- Royal Derby Hospital branch, School of Medicine, University of Nottingham — Derby, Derbyshire, United Kingdom (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.