Channa striata and Curcuma Domestica Supplements in Active Pulmonary TB

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study evaluates the use of a combined supplement containing Channa striata extract and Curcuma domestica rhizome alongside standard anti-TB therapy in adults with newly diagnosed pulmonary TB. Participants will be randomized to receive the supplement or a maltodextrin placebo, with assessment of nutritional status, inflammatory markers, and health-related quality of life. Enrollment targets adults aged 18 and older with BMI below 23, who have not yet received full anti-TB treatment. Exclusion criteria include pregnancy, overweight status, major comorbidities, drug-resistant TB, extrapulmonary TB, and recent use of similar supplements. The trial is conducted at the Nutrition Department of Universitas Sumatera Utara in Medan, Indonesia, led by Dina Keumala Sari.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female aged ≥18 years.
* Body Mass Index (BMI) \<22.9 kg/m².
* Newly diagnosed pulmonary tuberculosis (TB).
* Diagnosis confirmed by bacteriological and/or clinical-radiological findings.
* Have not received anti-tuberculosis treatment, or have received treatment for less than two weeks.
* Willing to participate in the study by providing written informed consent and signing the Informed Consent Form.

Exclusion Criteria:

* Pregnant or breastfeeding women.
* Individuals who are overweight or obese.
* Individuals with comorbidities such as diabetes mellitus, HIV, impaired kidney function, or impaired liver function.
* Patients with drug-resistant tuberculosis, including MDR-TB or XDR-TB, or patients who previously failed an anti-tuberculosis treatment regimen.
* Patients with extrapulmonary tuberculosis.
* Patients who have consumed snakehead fish supplements, curcuma supplements, or high-dose multivitamin supplements within the previous two weeks.
* Patients with a history of allergy to fish or turmeric-derived products. Patients with swallowing disorders or gastrointestinal diseases that may affect supplement absorption.
* Patients who are uncooperative or discontinue treatment before completing the study.

Where it's running

• Nutrition Department, Universitas sumatera utara, Medan, Indonesia
  Medan, North Sumatera, Indonesia Recruiting
• Nutrition Department, Universitas sumatera utara, Medan, Indonesia
  Medan, North Sumatera, Indonesia Recruiting

Study contacts

• Study coordinator: Aprillia Kusuma Putri
• Email: aprilliakusuma0104@gmail.com
• Phone: +628116590096

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• PAN-USR: a universal ultra-short treatment for pulmonary tuberculosis

  This trial tests whether a new 2–3 month drug regimen works and is safe for adults with active pulmonary tuberculosis, including drug-resistant cases.

  Recruiting at 3 sites Phase 3 Shenzhen Third People's Hospital · Beijing and 2 other locations · NCT06905522

• Shorter treatment for low-risk active tuberculosis

  This study is testing if a shorter 4-month treatment for low-risk pulmonary tuberculosis works just as well as the usual 6-month treatment for newly diagnosed patients.

  Recruiting at 8 sites Phase 3 Kaohsiung Veterans General Hospital. · New Taipei City, Bangiao and 7 other locations · NCT06727864

• Using breath analysis to identify multiple lung diseases

  This study is testing if analyzing breath samples can help identify different lung diseases like lung cancer and COPD in a large group of 10,000 people.

  Recruiting ChromX Health · Guangzhou, Guangdong · NCT06528418

• Using Atorvastatin to treat Pulmonary Tuberculosis

  This study is testing if adding Atorvastatin, a cholesterol-lowering drug, can help people with pulmonary tuberculosis get better when they start treatment.

  Recruiting at 8 sites Phase 2 Obafemi Awolowo University Teaching Hospital · Zaria, Kaduna State and 7 other locations · NCT06199921

• Rehabilitation for people recovering from tuberculosis lung disease

  This study is testing if a 12-week rehabilitation program can help people recovering from tuberculosis lung disease feel better and improve their daily activities compared to standard care.

  Recruiting at 2 sites Centro Universitário Augusto Motta · Rio de Janeiro and 1 other locations · NCT06127641

• New treatments for pulmonary tuberculosis

  This study is testing new combinations of two drugs with existing TB treatments to see if they can help people with pulmonary tuberculosis get better in a shorter time than the usual 24 weeks.

  Recruiting at 8 sites Phase 2 University College, London · Chisinau and 10 other locations · NCT06114628

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.