Changing magnesium and acid type in dialysis fluid to reduce clotting and immune activation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This nested monocentric sub-study enrolls participants from the multicenter OMAGOD pilot and uses a crossover design with three dialysate compositions given in two-week periods. Each participant receives standard hemodialysis while switching between citrate-acid and acetic-acid dialysates with different magnesium concentrations. During selected midweek sessions, serial blood samples are taken at baseline, hourly, and at the end of dialysis, and the used dialysis circuit is rinsed to collect adherent cells. Outcomes focus on immune cell activation, neutrophil extracellular trap formation, and other thromboinflammatory markers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants to the OMAGOD pilot trial

Exclusion Criteria:

* Patients who are not participating in the OMAGOD pilot trial

Where it's running

• Universitair Ziekenhuis Brussel
  Brussels, Belgium Recruiting

Study contacts

• Principal investigator: Florine Janssens, Medical doctor — (1)Department of Nephrology and Arterial Hypertension, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium. (2) Kidney diseases, dialysis & transplantation Research Unit (NIER), Vitality Research Group, Vrije Universiteit Brussel (VUB)
• Study coordinator: Florine Janssens, Medical doctor
• Email: florine.janssens@uzbrussel.be
• Phone: +324749435

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.