Cerebral Small Vessel Disease Progression by Stroke Type

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational study aiming to understand how cerebral small vessel disease (CSVD) evolves over time in relation to the type of ischemic stroke. Researchers will categorize participants based on MRI findings into CSVD without stroke, CSVD with lacunar stroke, or CSVD with territorial stroke and will measure blood biomarkers that may reflect CSVD course. Outcomes include neuropsychological and neurological function, quality of life, and stroke recurrence risk, with MRI to track CSVD changes. The study is conducted at University Hospital Ulm in Germany and focuses on adults with MRI-confirmed CSVD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Evidence of cerebral small vessel disease on brain MRI, defined as white matter hyperintensities (Fazekas grade 1-3)
* Assignment to one of the following study groups based on MRI findings:
* cerebral small vessel disease without evidence of an acute ischemic stroke
* cerebral small vessel disease with acute lacunar ischemic stroke
* cerebral small vessel disease with acute territorial ischemic stroke
* Ability to provide written informed consent
* Sufficient German language skills to understand study procedures and assessments

Exclusion Criteria:

* Alternative plausible causes of white matter hyperintensities other than cerebral small vessel disease (e.g. inflammatory central nervous system disorders, leukodystrophies, brain tumors)
* Known neurodegenerative diseases (e.g. Parkinson's disease, Alzheimer's disease, other dementias)
* Acute or recent traumatic brain injury
* Contraindications to magnetic resonance imaging
* Pregnancy or breastfeeding
* Life expectancy of less than one year
* Inability to comply with study procedures or follow-up visits

Where it's running

• University Hospital Ulm, Department of Neurology, Germany
  Ulm, Baden-Wurttemberg, Germany Recruiting

Study contacts

• Study coordinator: Mona E Laible, MD
• Email: mona.laible@uniklinik-ulm.de
• Phone: +49(0)7311770

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.