Care bundle to improve recovery after intracerebral haemorrhage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial implements a standardized Care Bundle for acute intracerebral haemorrhage that includes rapid reversal of oral anticoagulation (when indicated), early intensive blood pressure lowering, treatment of pyrexia, and control of hyperglycemia, alongside guidance on escalation or limitation of care. Participating hospitals will adopt the bundle as part of routine acute management and outcomes before and after implementation will be compared, with the primary endpoint measured at 3 months. The design emphasizes practical implementation across high‑income country centers to see whether benefits observed previously in lower‑ and middle‑income settings can be replicated. Eligibility focuses on adults with CT‑confirmed spontaneous ICH presenting within 24 hours, excluding patients with non-spontaneous causes, clinical brain herniation, or very limited life expectancy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults (age ≥18 years)
* Non-contrast computerized tomography (NCCT) imaging-verified diagnosis of spontaneous intracerebral haemorrhage
* ≤24 hours from symptom onset or presumed symptom onset (last seen well)

Exclusion Criteria:

* Previous care limitation
* End-stage comorbidity with short life-expectancy (\<6 m; e.g. terminal cancer)
* ICH caused by brain tumor or cerebral venous thrombosis
* Clinical signs of brain herniation at first presentation (unresponsive patient with bilaterally fixed, maximally dilated pupils)
* Pregnant women beyond 22 weeks gestation may only be included after thorough discussion with an obstetrician to determine risks vs benefit.

Where it's running

• The University of Oklahoma Health
  Oklahoma City, Oklahoma, United States Recruiting
• Royal Adelaide Hospital
  Adelaide, Australia Recruiting
• Monash Medical Centre
  Clayton, Australia Recruiting
• Health Sciences North/Health Sciences North Research Institute
  Greater Sudbury, Ontario, Canada Recruiting
• Hamilton General Hospital
  Hamilton, Ontario, Canada Recruiting
• Ottawa Hospital Research Institute
  Ottawa, Ontario, Canada Recruiting

+4 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Study coordinator: Teresa Ullberg, MD, PhD
• Email: i-catcher@med.lu.se
• Phone: 0046175057

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.