Cardio-oncology rehabilitation for women with breast cancer on chemotherapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial enrolls women with breast cancer who are planned for neoadjuvant or adjuvant chemotherapy. It aims to characterize cardiovascular and functional effects of chemotherapy and to evaluate an integrated cardio-oncology exercise rehabilitation program. The study uses a structured exercise intervention delivered within the cancer care setting to assess safety, feasibility, and potential benefits on cardiorespiratory fitness and overall well-being. Eligibility requires cardiovascular stability and clearance for exercise, while several preexisting cardiac or musculoskeletal conditions are exclusionary. The trial is conducted at Hospital de Clinicas de Porto Alegre in Porto Alegre, Brazil.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Diagnosis of breast cancer
2. Indicated for chemotherapy treatment
3. Cardiovascularly stable
4. Cleared for physical exercise
5. Willing to participate in the study
6. Physically able to perform the assessments and training sessions

Exclusion Criteria:

1. Any decompensated disease that would compromise the ability to perform the training sessions
2. Prior diagnosis of ischemic heart disease
3. Prior diagnosis of valvular heart disease
4. Prior diagnosis of cardiac arrhythmias
5. Myocarditis within the past 6 months
6. History of heart failure
7. LVEF \<55% prior to initiation of chemotherapy
8. Musculoskeletal disorders that limit the ability to perform the exercises
9. Diagnosis of peripheral arterial occlusive disease within the past 6 months
10. Ankle-brachial index \<0.4
11. Cognitive impairment that would compromise understanding of study procedures or participation

Where it's running

• Hospital de Clinicas de Porto Alegre
  Porto Alegre, Rio Grande do Sul, Brazil Recruiting

Study contacts

• Principal investigator: Rosane M Nery, PhD — Hospital de Clinicas de Porto Alegre
• Study coordinator: Rosane M Nery, PhD
• Email: rnery@hcpa.edu.br
• Phone: +55 51 33597634

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.