Can ultrasound of parasternal intercostal muscles and the diaphragm help predict if a patient will be weaned from the ventilator
Official title: Ultrasound Evaluation of Diaphragmatic Functions and Parasternal Intercostal Muscle Thickening Fraction as Predictors of Successful Weaning From Mechanical Ventilation.
Run by Ain Shams University · NCT07630662 · Data updated 2026-11-12
This study tests whether ultrasound measurements of the diaphragm and parasternal intercostal muscles can help predict successful weaning from mechanical ventilation in adults in the ICU.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 77 (estimated) |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | January 1, 2026 |
| Main results expected | July 1, 2026 |
| Study ends | August 1, 2026 |
| Registry record updated | June 5, 2026 |
| Trial ID | NCT07630662 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) on mechanical ventilation for more than 48 hours in Ain Shams University Hospitals who can provide consent or have a proxy to consent, without diaphragmatic paralysis or injury.
✕Probably not a fit
Patients with diaphragmatic injury or paralysis, or those unable to undergo ultrasound assessment, may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study examines whether ultrasound estimates of diaphragmatic and accessory respiratory muscle function can predict weaning outcomes in adults on ventilation for more than 48 hours. It focuses on the parasternal intercostal muscles alongside diaphragmatic function to understand load-sharing during weaning. The study notes that prolonged ventilation carries risks and aims to identify imaging markers that may indicate readiness for extubation. Ultrasound assessments will be performed in the ICU setting to explore inter-observer reliability and predictive value. The goal is to improve timing of extubation and reduce complications related to ventilation duration.
Why it matters
Potential benefit: If successful, this approach could help clinicians predict which patients are likely to wean successfully from the ventilator, potentially reducing time on ventilation and associated complications.
How similar studies have gone: Prior research supports diaphragmatic ultrasound for weaning, and this study adds evaluation of parasternal intercostal muscles for potential predictive value.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1\. Adult patients more than 18 years old. 2. Patient on mechanical ventilation more than 48 hours. Exclusion Criteria: * 1\. Declining to give a written informed consent. 2. Diaphragmatic paralysis or injury
Where it's running
-
Ain shams university hospitals
Cairo, Egypt Recruiting
Study contacts
- Study coordinator: Mohamed I Ezz eldein
- Email: mohamedislam@med.asu.edu.eg
- Phone: +2-1148394581
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.