Clinical trial Recruiting at 1 site Interventional Ages 30 to 70

Can switching to a prebiotic soda improve blood sugar in adults who regularly drink soda

Official title: A Randomized, Open-Label, Controlled Study to Evaluate the Effects of a Prebiotic Soda on Glycemic Control in Adults With Glucose Dysregulation

Run by Olipop, PBC · NCT07298135 · Data updated 2026-11-12

This study tests whether replacing usual non-diet soda with OLIPOP prebiotic soda for 8 weeks can improve blood sugar control in adults with glucose dysregulation who regularly drink soda.

More Glucose Control trials

Quick facts

Study typeInterventional
Ages30 Years to 70 Years
SexAll
Enrollment224 (estimated)
SponsorOlipop, PBC
Industry-sponsored
Locations1 site (Los Angeles, California)
StatusRecruiting
StartedDecember 17, 2025
Main results expectedDecember 2026
Study endsDecember 2026
Registry record updatedJuly 1, 2026
Trial IDNCT07298135 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 30–70 with BMI 25–35 kg/m² and fasting glucose 100–125 mg/dL or HbA1c 5.7–6.4%, who currently drink 2–3 servings of non-diet soda daily and have low fiber intake.

Probably not a fit

Those who do not experience changes in glucose control or who do not tolerate the prebiotic soda well may not see a benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized trial, adults aged 30–70 with mild glucose dysregulation will be assigned to continue their regular non-diet soda intake or switch to OLIPOP prebiotic soda (2 cans/day) for 8 weeks. The primary outcome is markers of glucose control, with secondary outcomes including long-term glycemic measures and insulin sensitivity. The study compares habitual soda consumption against a prebiotic beverage to see if gut-friendly fiber can influence metabolic health. Participants will maintain their usual diet and activity with the exception of the assigned beverage. The trial is sponsored by Olipop, with collaboration from People Science, and will take place in Los Angeles, CA.

Why it matters

Potential benefit: If successful, participants could see improved blood sugar markers and metabolic health from a simple beverage substitution.

How similar studies have gone: Previous research suggests that prebiotic fibers can favorably affect metabolic markers, but this specific beverage substitution is building on limited prior data.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Able to provide informed consent
* Willing to comply with all study procedures
* Male or female, ages 30 - 70 years old
* Habitual consumers of traditional non-diet soda (average intake 2 - 3 servings (24-36 fl. oz)/daily in a typical month, representing usual dietary pattern)
* BMI between 25 - 35 kg/m²
* Fasting plasma glucose between 100 - 125 mg/dL or hemoglobin A1c between 5.7% - 6.4%
* Low habitual dietary fiber intake, assessed using a qualitative fiber intake screening questionnaire administered at pre-screening
* Willing to maintain stable tobacco/nicotine use habits established for ≥ 90 days, with no initiation, cessation, or change in frequency during the study period
* Willing to maintain stable marijuana, hemp, and CBD product use habits established for ≥ 60 days, with no initiation, cessation, or change in frequency during the study period
* Willing to maintain habitual diet (with the exception of study products) and physical activity patterns throughout the trial

Exclusion Criteria:

* Inability to consume a standard 12 fl. oz. carbonated beverage twice daily
* Currently engaged or planning to be on an intensive weight loss regimen program
* Extreme dietary habits in the judgement of the Investigator or has been diagnosed with an eating disorder
* Habitual use of fiber supplements, inulin-based supplements, acacia fiber, glucomannan, prebiotic supplements, or probiotic supplements within 30 days of study enrollment
* Known allergy or sensitivity to any of the ingredients in the study products
* History or presence of uncontrolled and/or clinically important medical conditions that could interfere with study results interpretation (i.e., diabetes mellitus, CKD stage 4-5, severe liver disease/cirrhosis, uncontrolled hypertension, recent myocardial infarction or stroke (within 6 months), severe mental illness or cognitive impairment, immunodeficiency disorders, active infections).
* Gastrointestinal conditions that could potentially interfere with absorption of the study product (i.e., IBD, celiac disease, short bowel syndrome, chronic pancreatitis, gastroparesis, active peptic ulcer disease, gastric bypass or other bariatric surgeries, severe IBS, chronic diarrhea or malabsorption syndromes, active diverticulitis)
* Use of oral or injectable steroids within 90 days of enrollment
* Use of antibiotic therapy within 90 days of enrollment
* Unstable use of prescription medications within 90 days of enrollment that affect plasma glucose levels (e.g., corticosteroids, thiazide diuretics, beta-blockers (some types), antipsychotics, tacrolimus, protease inhibitors, ACE inhibitors)
* Use of any of the following prescription medications within 90 days of enrollment: Metformin, sulfonylureas, GLP-1 agonists, SGLT-2 inhibitors, insulin.
* History or presence of cancer, except non-melanoma skin cancer, within 2 years of enrollment
* Exposure to any non-registered drug product or participation in another intervention study within 30 days prior to enrollment
* Recent history (within 12 months) of alcohol or substance abuse
* History of major trauma or surgical event within 60 days of enrollment
* Person who is pregnant, planning pregnancy, or lactating
* Any condition the Investigator believes would interfere with study participation or compliance
* Consumption of more than 5 prebiotic sodas within the last 30 days prior to enrollment
* Heavy smoker as defined as smoking 20 or more cigarettes per day, or smoked roughly 1 pack a day for 20+ years (more than 20 pack years)

Where it's running

  • People Science
    Los Angeles, California, United States
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.