Daily multivitamin/mineral supplements to improve metabolic, muscle, and mental health in midlife Asian women
Impact of Supplementation in Improving Metabolic Health Outcomes (ISMOS) Study
This trial will test whether taking a daily multivitamin and mineral supplement for 12 months improves metabolism, mood, and muscle health in Asian women aged 40–60.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 400 (estimated) |
| Ages | 40 Years to 60 Years |
| Sex | Female |
| Sponsor | Institute for Human Development and Potential (IHDP), Singapore Academic / other |
| Locations | 1 site (Singapore) |
| Trial ID | NCT07433049 on ClinicalTrials.gov |
What this trial studies
This randomized, double-blind, placebo-controlled trial will give eligible midlife Asian women either a daily multivitamin/mineral (MVM) supplement or placebo for 12 months. Outcomes include change in MetaboAge and a range of metabolic, mental health, and musculoskeletal measures such as insulin sensitivity, mood scores, and muscle function. Participants are women aged 40–60 of Chinese, Malay, or Indian ethnicity with BMI 23–35 kg/m2, and those with major comorbidities or conflicting supplement use are excluded. The trial is conducted at the Institute for Human Development and Potential in Singapore and is designed to test whether improving micronutrient status can modify midlife health trajectories.
Who should consider this trial
Good fit: Asian (Chinese, Malay, or Indian) women aged 40–60 years with BMI 23.0–35.0 kg/m2, proficient in English and willing to follow the protocol, are the intended participants.
Not a fit: Women with diagnosed diabetes, recent cancer, autoimmune disease, those taking certain medications or overlapping supplements, or planning major diet or medical changes are unlikely to benefit from this intervention.
Why it matters
Potential benefit: If successful, the supplement could lower biological metabolic age and improve metabolic markers, mood, and muscle function, potentially reducing longer-term chronic disease risk.
How similar studies have performed: Observational studies have linked higher B-vitamin and vitamin D levels with better metabolic and mental health, but randomized trials of broad MVM supplements in midlife Asian women are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women aged 40-60 years old * Chinese, Malay or Indian * BMI between 23.0-35.0 kg/m2 * Proficient in English language * Willing to comply with study protocol \& provide informed consent Exclusion Criteria: * Pregnant or planning a pregnancy * Diagnosis with Diabetes, Polycystic Ovary Syndrome (PCOS), autoimmune diseases, chronic organ failure, severe heart disease, eating disorders and/or other medical conditions which in the PI's judgment which may affect study outcomes * Fasting glucose value ≥ 7.0 mmol/L * Active cancer or treatment of cancer in the last 3 years * Participating in other nutritional intervention studies * Taking oral corticosteroids, anti-psychotic and/or weight loss drugs * Having planned hospitalization in the next 12 months * Planning to have major diet changes in the next 12 months * Taking a medically prescribed supplement(s) that contains 3 or more of the ingredients of the study product * Taking a non-prescribed supplement(s) that contains 3 or more of the ingredients of the study product in the last 1 month
Where this trial is running
Singapore
- Institute for Human Development and Potential (IHDP) — Singapore, Singapore (Recruiting)
Study contacts
- Study coordinator: Johan Eriksson, MD
- Email: johan_eriksson@a-star.edu.sg
- Phone: 80616604
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.