Calcium Gluconate After Birth to Reduce Blood Loss in Vaginal Delivery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, double-blind, placebo-controlled trial investigates whether intravenous calcium gluconate given immediately after umbilical cord clamping reduces postpartum blood loss in vaginal delivery. Participants are assigned 1:1 to receive either calcium gluconate or a saline placebo, with blinding maintained for participants, clinicians, and outcome assessors. The co-primary outcomes include the proportion of participants whose postpartum hemoglobin declines by at least 2 g/dL from pre-delivery values to the lowest point after birth. The study addresses potential mechanisms linking calcium to uterine contraction and coagulation, and aims to determine if supplementation improves postpartum recovery. Eligible are adults planning vaginal delivery at term, while certain medical conditions and treatments exclude participation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Gestational age of 37 weeks or more, and planning a vaginal delivery.

Exclusion Criteria:

* Age younger than 18 years old.
* Patients treated with calcium channel blockers
* Patients with Preeclampsia with severe features receiving magnesium sulfate infusion.
* Chronic renal failure and hyperphosphatemia
* Patients with known Para-Thyroid disease
* Sarcoidosis

Where it's running

• Rambam Medical Center
  Haifa, Israel Recruiting

Study contacts

• Study coordinator: Gili Buchnik Fater, MD
• Email: gili.buchnik@gmail.com
• Phone: +972546738628

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.