Condition
Opioid Use Disorder, Severe clinical trials and research
As of November 12, 2026, Find a Trial lists 3 Opioid Use Disorder, Severe clinical trials that are recruiting, at sites in 2 countries (most in United States (2), Taiwan (1)). By phase: Phase 2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 2Countries
Newest Opioid Use Disorder, Severe clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Low-Intensity Focused Ultrasound for Severe Opioid or Amphetamine Use Disorder | — | Taipei | Recruiting | Jul 29, 2026 |
| Buprenorphine access at syringe service programs to reduce overdoses | — | Los Angeles, California and 7 other locations | Recruiting | Jun 8, 2026 |
| Tirzepatide with buprenorphine for opioid use disorder | Phase 2 | Jacksonville, Florida and 8 other locations | Recruiting | Oct 21, 2024 |
All recruiting trials (3)
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Low-Intensity Focused Ultrasound for Severe Opioid or Amphetamine Use Disorder
This study tests whether a single session of low-intensity focused ultrasound to the nucleus accumbens is tolerable and may help treat people with severe opioid or amphetamine use disorders.
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Buprenorphine access at syringe service programs to reduce overdoses
This study tests whether offering buprenorphine directly at syringe service programs helps adults with opioid use disorder start and stay in treatment better than referring them to traditional clinics.
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Tirzepatide with buprenorphine for opioid use disorder
This trial will test whether adding weekly tirzepatide injections to buprenorphine helps adults with moderate to severe opioid use disorder stay in treatment, reduce opioid use, and improve sleep.
Related topics
Quick answers
How many Opioid Use Disorder, Severe clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 2 countries. The most sites are in United States (2 trials), Taiwan (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.