Breathing new life into neck pain: brain activity and six weeks of physiotherapy
Official title: Predictors of Response After Physiotherapy Treatment in People With Chronic Non-specific Neck Pain
Run by University of Deusto · NCT07756229 · Data updated 2026-11-12
This study tests whether brain activity measured by EEG changes after six weeks of manual therapy and neck exercises in adults with chronic neck pain.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of Deusto Academic / other |
| Locations | 1 site (San Sebastián, Guipuzcoa) |
| Status | Recruiting |
| Started | March 21, 2024 |
| Main results expected | March 2027 |
| Study ends | December 2027 |
| Registry record updated | September 25, 2026 |
| Trial ID | NCT07756229 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with chronic non-specific neck pain lasting more than 3 months who are willing to consent.
✕Probably not a fit
Individuals with neurological or psychiatric diseases (other than depression) or those with surgical cervical spine history or severe systemic conditions may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this non-randomized interventional study, adults with chronic non-specific neck pain will receive six weekly physiotherapy sessions, including manual mobilizations and a neck-specific exercise program with a home routine. Participants will have baseline clinical questionnaires, pain mapping, quantitative sensory testing, and 64-channel EEG, with follow-up assessments about one week after treatment and roughly 12 weeks later to gauge recovery and disability. A healthy control group is included for reference data. The study aims to relate EEG features to clinical symptoms and determine whether brain and clinical measures shift after physiotherapy.
Why it matters
Potential benefit: If successful, patients may experience reduced pain and neck-related disability following physiotherapy, with potential brain activity changes that correlate with clinical improvements.
How similar studies have gone: Previous work in similar non-randomized designs has shown changes in brain activity associated with musculoskeletal pain after therapy, but this exact combination with EEG and neck physiotherapy is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Chronic non-specific neck pain (\>3 months duration) * Willing and able to sign informed consent for study participation Exclusion Criteria: * Concomitant neurological or psychiatric disease apart from depression (especially severe mental disorder or psychopathology) * Regular (daily) intake of benzodiazepines * Signs of severe disease, cervical myelopathy, tumour, rheumatic diseases or a neurological pathology of central origin * Neck pain of traumatic origin or as a result of whiplash * Previous surgical intervention of the cervical spine
Where it's running
-
Ander Cervantes Benítez
San Sebastián, Guipuzcoa, Spain Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.