Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Breathing new life into neck pain: brain activity and six weeks of physiotherapy

Official title: Predictors of Response After Physiotherapy Treatment in People With Chronic Non-specific Neck Pain

Run by University of Deusto · NCT07756229 · Data updated 2026-11-12

This study tests whether brain activity measured by EEG changes after six weeks of manual therapy and neck exercises in adults with chronic neck pain.

More Chronic Neck Pain trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorUniversity of Deusto
Academic / other
Locations1 site (San Sebastián, Guipuzcoa)
StatusRecruiting
StartedMarch 21, 2024
Main results expectedMarch 2027
Study endsDecember 2027
Registry record updatedSeptember 25, 2026
Trial IDNCT07756229 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with chronic non-specific neck pain lasting more than 3 months who are willing to consent.

Probably not a fit

Individuals with neurological or psychiatric diseases (other than depression) or those with surgical cervical spine history or severe systemic conditions may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this non-randomized interventional study, adults with chronic non-specific neck pain will receive six weekly physiotherapy sessions, including manual mobilizations and a neck-specific exercise program with a home routine. Participants will have baseline clinical questionnaires, pain mapping, quantitative sensory testing, and 64-channel EEG, with follow-up assessments about one week after treatment and roughly 12 weeks later to gauge recovery and disability. A healthy control group is included for reference data. The study aims to relate EEG features to clinical symptoms and determine whether brain and clinical measures shift after physiotherapy.

Why it matters

Potential benefit: If successful, patients may experience reduced pain and neck-related disability following physiotherapy, with potential brain activity changes that correlate with clinical improvements.

How similar studies have gone: Previous work in similar non-randomized designs has shown changes in brain activity associated with musculoskeletal pain after therapy, but this exact combination with EEG and neck physiotherapy is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Chronic non-specific neck pain (\>3 months duration)
* Willing and able to sign informed consent for study participation

Exclusion Criteria:

* Concomitant neurological or psychiatric disease apart from depression (especially severe mental disorder or psychopathology)
* Regular (daily) intake of benzodiazepines
* Signs of severe disease, cervical myelopathy, tumour, rheumatic diseases or a neurological pathology of central origin
* Neck pain of traumatic origin or as a result of whiplash
* Previous surgical intervention of the cervical spine

Where it's running

  • Ander Cervantes Benítez
    San Sebastián, Guipuzcoa, Spain
    Recruiting

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.