Breathing high oxygen levels to improve function after spinal cord injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This proof-of-principle study investigates whether brief exposure to high concentrations of oxygen can enhance sensory and motor functions in individuals with subacute or chronic severe spinal cord injuries. Participants will undergo four experimental sessions where their reflex and sensory functions will be assessed before and after inhaling either room air or 99% oxygen for two minutes. The study aims to determine if this short exposure leads to measurable improvements in function, potentially paving the way for further therapeutic exploration. The safety of high oxygen exposure has been previously established in various injury contexts.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Individuals with traumatic SCI with onset ≥3 months prior,
2. Between 18 - 65 yr old,
3. ASIA Impairment Scale at discharge classified as A, B or C,
4. Injury level between C5 and T10,
5. Able to give informed, written consent.

Exclusion Criteria:

1. Frequent uncontrolled autonomic dysreflexia,
2. Uncontrolled high blood pressure,
3. Cardiac or cardiovascular disease,
4. Cancer,
5. Active urinary tract infection,
6. Active pressure sores,
7. Signs of deep vein thrombosis in the legs,
8. Severe swelling of the feet and/or legs,
9. Severe cognitive impairment,
10. Pulmonary dysfunction such as chronic obstructive pulmonary disease or acute respiratory infection,
11. Any condition which would be exacerbated by sitting or lying in one position for 2 hours, such as low back pain
12. Pregnancy.

Where it's running

• University of Alberta, Clinical Sciences Bldg
  Edmonton, Alberta, Canada Recruiting

Study contacts

• Principal investigator: Jaynie Yang — University of Alberta
• Study coordinator: Michelle Barnes, PT
• Email: carre@ualberta.ca
• Phone: 780-492-4858

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.