Brain MRI of teenage girls with borderline personality disorder, with and without PTSD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional imaging project enrolls female adolescents (13–17) with borderline personality disorder, some of whom also meet criteria for PTSD, plus a healthy control group, and collects brain MRI data. The primary focus is on hippocampal volume and hippocampal subfields, with additional analyses of fronto-limbic white matter and resting brain activity. Clinical measures of general psychopathology, PTSD symptom intensity, attachment, emotion regulation, attention/executive function, mentalization, and autobiographical memory are collected and linked to imaging findings. Participants are followed cross-sectionally and with a planned 18-month longitudinal link between brain measures and symptom trajectories.

Why it matters

Who can join: the full rules

Inclusion Criteria:

For the 3 groups:

* female
* Age between 13 and 17 years inclusive
* Oral and written comprehension of the French language
* Affiliation to the social security scheme
* Informed consent signed by the legal representatives holding the exercise of parental authority and the adolescent herself

For patients:

* Diagnosis of borderline personality disorder according to the criteria of the Diagnostic and Statistical Manual for mental disorders, fifth edition (DSM-5; American Psychiatric Association, 2013; SIDP-IV)
* Level of general psychopathology compatible with participation in the study (score\> 20 on the CGA-S)

TB + / PTSD + group:

\- Post-traumatic stress disorder according to DSM-5 criteria (American Psychiatric Association, 2013; K-SADS-PL)

In the control group :

* Absence of mental disorder according to DSM-5 criteria (American Psychiatric Association, 2013; K-SADS-PL and SIDP-IV)
* Oral and written comprehension of the French language
* Informed consent signed by the legal representative, the holder (s) of the exercise of parental authority and the adolescent herself

Exclusion Criteria:

* \- Illiteracy / illiteracy
* Sensory disorder (visual, auditory)
* Severe chronic psychiatric comorbidity: autism spectrum disorder, intellectual disability, schizophrenia spectrum disorder and other psychotic disorders, bipolar disorder
* Severe or current brain pathology (chronic neurological disease, encephalitis, history of severe head trauma), alertness disorder
* History of anoxic coma
* Contraindication to MRI (magnetic foreign body, claustrophobia, contraindication to prolonged lying down)
* Severe physical pathology in progress
* Moving outside the Normandy region planned within 18 months
* The inclusion of the subject in another biomedical research protocol (during the present study)
* Intellectual deficit (IQ \<70)
* Pregnant or breastfeeding women

Where it's running

• Caen University Hospital
  Caen, France Recruiting

Study contacts

• Study coordinator: Fabian Guénolé, Pr.
• Email: guenole-f@chu-caen.fr
• Phone: +33 (0) 231 272 309

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.