Brain blood flow changes after successful clot removal in acute ischemic stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational, longitudinal imaging study that uses blood oxygenation–level dependent cerebrovascular reactivity (BOLD-CVR) MRI with breathing maneuvers to track brain blood flow changes after endovascular thrombectomy. Adult patients with ICA, MCA, or tandem occlusions who achieve successful recanalization (mTICI ≥2b) will be enrolled and undergo serial BOLD-CVR scans during hospitalization and follow-up. No experimental treatments are given; imaging findings will be compared with clinical outcomes to identify patterns associated with reperfusion failure. The goal is to determine whether BOLD-CVR changes can serve as an imaging biomarker for clinically ineffective reperfusion.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male and female subjects \>18 years old.
* Acute ischemic stroke related to a new occlusion of the internal carotid artery, middle cerebral artery (M1- and/or M2-segment), or both.
* Eligibility and performance of endovascular thrombectomy.
* Achievement of successful recanalization, defined as mTICI score ≥2b
* Written informed consent of the patient or when the patient is not able to participate in the consenting procedure, the written authorization of a family member. Foreign speaking patients should be included by a person with sufficient German language proficiency to act as a translator.

Exclusion Criteria:

* Documented evidence or a confirmed willingness of the patient not to participate in any scientific study.
* Standard contraindications for MRI, such as pacemaker, metallic prothesis, glaucoma, metallic tattoo dyes, verbal confirmed pregnancy. Unwilling or unable to cooperate with breathing manoeuvres.
* Major cardiopulmonary diseases, such as severe uncontrolled asthma bronchiale, severe chronic obstructive lung disease (i.e., GOLD stage ≥III), diffuse interstitial lung disease, pulmonary embolism, acute/subacute myocardial infarction, or severe heart failure (i.e., NYHA class ≥III).
* Symptomatic increased intracranial pressure.
* Presence of intracranial haemorrhage type ≥2 according to the Heidelberg classification.
* New onset of seizure.

Where it's running

• Zurich University Hospital
  Zurich, Canton of Zurich, Switzerland Recruiting

Study contacts

• Principal investigator: Jorn Fierstra, Prof Dr. med., PhD — University of Zurich
• Study coordinator: Meltem Gönel, Dr. med.
• Email: meltem.goenel@usz.ch
• Phone: 43 253 90 19

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Very high-power short-duration vs standard low-power radiofrequency ablation for atrial fibrillation

  This trial tests whether very high-power short-duration ablation (90 W) is as safe and more effective than conventional low-power ablation (35-45 W) for treating atrial fibrillation.

  Recruiting Bakulev Scientific Center of Cardiovascular Surgery · Moscow · NCT07728539

• Intra-arterial Alteplase after successful reperfusion following mechanical thrombectomy

  This trial tests whether giving a small amount of alteplase directly into the artery after a successful thrombectomy helps adults with acute ischemic stroke recover better.

  Recruiting at 9 sites Phase 3 115 People's Hospital · An Giang and 12 other locations · NCT07727395

• Sivelestat added to endovascular clot retrieval for acute anterior circulation stroke

  This study tests whether giving sivelestat sodium alongside mechanical thrombectomy helps improve outcomes for adults with acute ischemic stroke due to large vessel occlusion.

  Recruiting at 2 sites Xuanwu Hospital, Beijing · Weifang, Shandong and 1 other locations · NCT07552610

• Adenosine given before primary PCI to reduce no-reflow in STEMI patients.

  See if giving intracoronary adenosine before primary PCI lowers the chance of slow flow/no-reflow in adults with STEMI.

  Recruiting at 2 sites Phase 4 National Institute of Cardiovascular Diseases, Pakistan · Karachi, Sindh and 1 other locations · NCT07536802

• Injecting methylprednisolone into the artery right after clot removal for large-vessel stroke

  This trial will test whether giving methylprednisolone into the artery immediately after successful clot removal, followed by three days of IV methylprednisolone, helps adults with anterior large-vessel occlusion strokes recover better.

  Recruiting Phase 2 Tang-Du Hospital · Xi'an, Shaanxi · NCT07516522

• Michigan experience using the Tigertriever device to remove brain clots

  This project tries to see if the Tigertriever device safely and effectively removes large brain clots in adults who have an ischemic stroke within 8 hours of symptom onset.

  Recruiting Henry Ford Health System · Detroit, Michigan · NCT07363525

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.