Body donation in HHT

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project analyzes tissue samples from individuals with hereditary hemorrhagic telangiectasia (HHT) to investigate how blood vessel malformations form. Researchers will compare tissues with and without vascular malformations to identify structural changes and potential disease mechanisms. The work builds on known genetic factors and suggests that local events beyond mutations contribute to malformation development. Ethical considerations limit sampling from living patients, so the study focuses on donated tissue to avoid clinical risk. The study is conducted by the University Hospital Essen and collaborating centers in Germany.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* positiv genetic testing for HHT and/ or at least three fulfilled Curacao Criteria
* older than 18 years

Exclusion Criteria:

* missing inclusion criteria

Where it's running

• Institut für Anatomie und Klinik für HNO-Heilkunde, Universitätsklinik Essen
  Essen, North Rhine-Westphalia, Germany Recruiting

Study contacts

• Study coordinator: Freya Droege
• Email: freya.droege@uk-essen.de
• Phone: 0049201723

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Engasertib for moderate to severe HHT: see if daily 40 mg helps with nosebleeds

  This trial tests whether taking engasertib once daily for 28 weeks reduces nosebleed frequency in adults with hereditary hemorrhagic telangiectasia compared with placebo.

  Recruiting at 4 sites Phase 3 Vaderis Therapeutics AG · Chicago, Illinois and 3 other locations · NCT07743671

• DIAG723 in Adults With HHT

  A first-in-human study tests DIAG723 versus placebo in adults with hereditary hemorrhagic telangiectasia to see if it is safe and possibly helpful.

  Recruiting at 3 sites Phase 1/2 Diagonal Therapeutics, Inc. · Camperdown, New South Wales and 10 other locations · NCT07623525

• Registry for patients with Hereditary Hemorrhagic Telangiectasia

  This study is collecting information from people with Hereditary Hemorrhagic Telangiectasia to better understand the condition and help improve treatments in the future.

  Recruiting at 16 sites Cure HHT · Birmingham, Alabama and 15 other locations · NCT06259292

• Evaluating Antiplatelet and Anticoagulation Therapy in Hereditary Hemorrhagic Telangiectasia

  This study is testing how well people with Hereditary Hemorrhagic Telangiectasia can handle new blood-thinning treatments compared to not using them, to find out which ones work best for them.

  Recruiting at 13 sites University Hospital, Clermont-Ferrand · Angers and 17 other locations · NCT05641142

• Examining the role of hypoxia in hereditary hemorrhagic telangiectasia

  This study looks at how low oxygen levels might affect people with hereditary hemorrhagic telangiectasia (HHT) and how it could change the way the disease develops.

  Recruiting University Hospital, Essen · Essen, North Rhine-Westphalia · NCT04469517

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.