Examining the role of hypoxia in hereditary hemorrhagic telangiectasia
Influence of Hypoxic Induced Factors in Patients With Hereditary Hemorrhagic Telangiectasia (HHT)
This study looks at how low oxygen levels might affect people with hereditary hemorrhagic telangiectasia (HHT) and how it could change the way the disease develops.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Essen Academic / other |
| Locations | 1 site (Essen, North Rhine-Westphalia) |
| Trial ID | NCT04469517 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the influence of hypoxic induced factors on patients with hereditary hemorrhagic telangiectasia (HHT), a genetic disorder characterized by systemic vascular malformations. It aims to understand how environmental factors, particularly hypoxia, may contribute to the disease's progression and severity. The study will analyze patients diagnosed with HHT to explore the relationship between hypoxia and angiogenesis, which is crucial for understanding the underlying mechanisms of the condition.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with hereditary hemorrhagic telangiectasia who are over 17 years old and able to provide consent.
Not a fit: Patients who do not meet the diagnostic criteria for hereditary hemorrhagic telangiectasia or are younger than 17 years may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and management strategies for patients with hereditary hemorrhagic telangiectasia.
How similar studies have performed: While the specific focus on hypoxic induced factors in HHT is novel, similar studies exploring environmental influences on genetic conditions have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * diagnosed HHT (genetic testing and/ or fulfill at least 3 Curacao Criteria) * older than 17 years * ability to consent Exclusion Criteria: * if inclusion Criteria are not met
Where this trial is running
Essen, North Rhine-Westphalia
- University Hospital Essen — Essen, North Rhine-Westphalia, Germany (Recruiting)
Study contacts
- Principal investigator: Freya Droege, MD — University hospital Essen Otorhinolaryngology, Hufelandstr. 55, 45147 Essen, Germany
- Study coordinator: Freya Droege, MD
- Email: freya.droege@uk-essen.de
- Phone: 0049201 723
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.