BMS-986528 in people with hard-to-treat rheumatoid arthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an early-phase interventional study evaluating BMS-986528 in adults with refractory rheumatoid arthritis. It aims to characterize safety, tolerability, pharmacokinetics and pharmacodynamics, and to gather preliminary evidence of disease-modifying activity. The trial includes phase 1/2 components and will be conducted at sites in California under Bristol-Myers Squibb sponsorship. Participants will receive BMS-986528 and will be assessed for adverse events, drug exposure, and signs of clinical response. The study excludes juvenile-onset arthritis, seronegative RA with possible polymyalgia rheumatica, and active fibromyalgia that could confound joint assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria

\- Adult participants with rheumatoid arthritis (RA) who meet definition of difficult-to-treat.

Exclusion Criteria

* Juvenile arthritis or onset of inflammatory arthritis before age 18.
* Seronegative RA participants in whom polymyalgia rheumatica has not been ruled out.
* Active fibromyalgia with pain symptoms or signs that would interfere with joint assessment.
* Other protocol-defined Inclusion/Exclusion criteria apply.

Where it's running

• Colorado Blood Cancer Institute
  Denver, Colorado, United States Recruiting
• Charité Research Organisation
  Berlin, Germany Recruiting
• Rheumazentrum Ruhrgebiet
  Herne, Germany Recruiting
• St. Josef-Stift Sendenhorst
  Sendenhorst, Germany Recruiting
• Istituto Clinico Humanitas
  Rozzano, Milano, Italy Recruiting
• Fondazione Policlinico Gemelli IRCCS
  Roma, Italy Recruiting

Study contacts

• Study coordinator: BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
• Email: Clinical.Trials@bms.com
• Phone: 855-907-3286

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.