Effects of a high-fiber diet on gut health and rheumatoid arthritis symptoms
Official title: Einfluss Ballaststoffreicher Ernährung Auf Das Mikrobiom Und Die Krankheitsaktivität Von Patientinnen Und Patienten Mit Rheumatoider Arthritis
Run by Wuerzburg University Hospital · NCT06492200 · Data updated 2026-11-12
This study is testing if a high-fiber diet can improve gut health and reduce symptoms for adults with rheumatoid arthritis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 52 (estimated) |
| Sponsor | Wuerzburg University Hospital Academic / other |
| Locations | 1 site (Würzburg) |
| Status | Recruiting |
| Started | June 1, 2024 |
| Main results expected | June 1, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | July 9, 2024 |
| Trial ID | NCT06492200 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 years old with a confirmed diagnosis of rheumatoid arthritis.
✕Probably not a fit
Patients with chronic inflammatory bowel disease or those who have recently used antibiotics may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to determine whether increasing dietary fiber can enhance the gut microbiome and alleviate symptoms in adults with rheumatoid arthritis (RA). Participants will be divided into two groups: one receiving dietary counseling and 10 grams of psyllium husk daily, while the other continues their usual diet. The study will monitor changes in gut bacteria, production of beneficial short-chain fatty acids (SCFAs), RA activity, and body weight over a 12-month period. Regular dietary support and questionnaires will be utilized to assess the impact of the dietary changes.
Why it matters
Potential benefit: If successful, this approach could lead to improved management of rheumatoid arthritis symptoms and overall health through dietary modifications.
How similar studies have gone: While the role of the gut microbiome in RA is emerging, this specific dietary intervention has not been extensively tested in previous studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients over 18 years old * Diagnosis of Rheumatoid Arthritis according to the ACR criteria of 2010 * The patient can understand the scope of the study and consents in writing to participate. Exclusion Criteria: * Age under 18 * Lack of consent capability * Insufficient knowledge of the German language * Chronic inflammatory bowel disease * Liver cirrhosis * History of mechanical ileus * Patients with altered gastrointestinal passage (e.g., stoma patients) * Use of antibiotics within the past three months * Use of ground psyllium husks four weeks prior to study inclusion
Where it's running
-
University Würzburg
Würzburg, Germany Recruiting
Study contacts
- Principal investigator: Eva C Schwaneck, M.D. — University Wuerzburg
- Study coordinator: Eva C Schwaneck, M.D.
- Email: e.schwaneck@rheuma-hh.de
- Phone: +49 40 1818 81 8343
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.