Effects of a high-fiber diet on gut health and rheumatoid arthritis symptoms
Einfluss Ballaststoffreicher Ernährung Auf Das Mikrobiom Und Die Krankheitsaktivität Von Patientinnen Und Patienten Mit Rheumatoider Arthritis
This study is testing if a high-fiber diet can improve gut health and reduce symptoms for adults with rheumatoid arthritis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 52 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | Wuerzburg University Hospital Academic / other |
| Locations | 1 site (Würzburg) |
| Trial ID | NCT06492200 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to determine whether increasing dietary fiber can enhance the gut microbiome and alleviate symptoms in adults with rheumatoid arthritis (RA). Participants will be divided into two groups: one receiving dietary counseling and 10 grams of psyllium husk daily, while the other continues their usual diet. The study will monitor changes in gut bacteria, production of beneficial short-chain fatty acids (SCFAs), RA activity, and body weight over a 12-month period. Regular dietary support and questionnaires will be utilized to assess the impact of the dietary changes.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with a confirmed diagnosis of rheumatoid arthritis.
Not a fit: Patients with chronic inflammatory bowel disease or those who have recently used antibiotics may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved management of rheumatoid arthritis symptoms and overall health through dietary modifications.
How similar studies have performed: While the role of the gut microbiome in RA is emerging, this specific dietary intervention has not been extensively tested in previous studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients over 18 years old * Diagnosis of Rheumatoid Arthritis according to the ACR criteria of 2010 * The patient can understand the scope of the study and consents in writing to participate. Exclusion Criteria: * Age under 18 * Lack of consent capability * Insufficient knowledge of the German language * Chronic inflammatory bowel disease * Liver cirrhosis * History of mechanical ileus * Patients with altered gastrointestinal passage (e.g., stoma patients) * Use of antibiotics within the past three months * Use of ground psyllium husks four weeks prior to study inclusion
Where this trial is running
Würzburg
- University Würzburg — Würzburg, Germany (Recruiting)
Study contacts
- Principal investigator: Eva C Schwaneck, M.D. — University Wuerzburg
- Study coordinator: Eva C Schwaneck, M.D.
- Email: e.schwaneck@rheuma-hh.de
- Phone: +49 40 1818 81 8343
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.