Blue diode laser vaporization for enlarged prostate (BPH)
Official title: Blue Diode Laser Vaporization for BPH
Run by Chinese University of Hong Kong · NCT07115147 · Data updated 2026-11-12
It tests whether a 450 nm blue diode laser vaporization can improve urinary symptoms in men aged 50 and older with symptomatic BPH.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years and up |
| Sex | Men only |
| Enrollment | 10 (estimated) |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Status | Recruiting |
| Started | June 26, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | March 31, 2027 |
| Registry record updated | November 3, 2026 |
| Trial ID | NCT07115147 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Men aged 50 years or older with symptomatic benign prostatic hyperplasia who are fit for the procedure and anesthesia are ideal candidates.
✕Probably not a fit
Patients with prior TURP, known prostate cancer, urethral stricture, bladder stones, significant neurological bladder dysfunction, active urinary infection, or who cannot undergo anesthesia are unlikely to be eligible or benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, single-arm study using a 450 nm blue diode laser to vaporize prostate tissue in men with symptomatic BPH. Each participant is followed for one year with visits at 3, 6, and 12 months after the operation. Clinical follow-up includes blood and urine tests, prostate ultrasound for volume, uroflowmetry, and symptom questionnaires, and all adverse events and unplanned admissions are recorded. The study aims to document safety and clinical outcomes of the blue diode vaporization technique.
Why it matters
Potential benefit: If successful, the procedure could reduce urinary symptoms and improve urine flow using a minimally invasive laser vaporization approach.
How similar studies have gone: Other laser treatments for BPH (for example, green and holmium lasers) have demonstrated good outcomes, but the 450 nm blue diode approach is novel and currently has limited published data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male ≥ 50 years * Symptomatic BPH Exclusion Criteria: * Additional procedure is needed e.g. cystolithotripsy, orchidectomy etc2. Known Ca prostate patients * Patients with history of TURP * Known Urethral stricture / Bladder stone / Hypercontractile bladder * Known neurological diseases which may affect bladder function (e.g. Parkinsonism, stroke) 6. Contraindicated to undergo TURP (e.g. not fit for GA/SA, active urinary tract infection, fail to be placed in lithotomy position, uncorrectable coagulopathy, antiplatelet or anticoagulant which cannot be stopped)
Where it's running
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Prince of Wales Hospital, Chinese University of Hong Kong
Hong Kong, Hong Kong Recruiting
Study contacts
- Principal investigator: Ka Fung Peter CHIU, MBChB PhD — Chinese University of Hong Kong
- Study coordinator: Ka Fung Peter CHIU, MBChB PhD
- Email: peterchiu@surgery.cuhk.edu.hk
- Phone: 35052625
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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INTUPRO for benign prostate enlargement symptoms
This trial will try INTUPRO to see if it improves urinary symptoms in men 45 and older with enlarged prostates (BPH).
-
Ultrasound imaging to assess lower urinary tract symptoms
This study is testing a new, cost-effective ultrasound method to see how well it can measure bladder function in men with lower urinary tract symptoms and benign prostatic hyperplasia.
-
Group pelvic floor training before prostate surgery
This study is testing if group pelvic floor training before prostate surgery can help men with benign prostatic hyperplasia avoid urinary incontinence after their operation.
-
Using loop diuretics to improve same-day discharge after prostate surgery
This study is testing if giving a diuretic during prostate surgery can help men go home the same day by improving their recovery and reducing complications.
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Evaluating Tryptophan for Treating BPH Symptoms
This study is testing whether Tryptophan can help men with BPH symptoms feel better without the sexual side effects that come with usual treatments.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.