Blood markers linked to thinking and memory problems after bladder tumor surgery
Association of Perioperative Cognitive Dysfunction With Circulating Biomarkers of Neurological Damage in Patients Underging Transurethral Resection of Bladder Tumor
Osijek University Hospital · NCT07165236
This project will see if certain blood biomarkers are linked to thinking and memory problems after transurethral removal of bladder tumors in adults having general anesthesia.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 42 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Osijek University Hospital (other) |
| Locations | 1 site (Osijek, Croatia) |
| Trial ID | NCT07165236 on ClinicalTrials.gov |
What this trial studies
This observational study will enroll adult patients (18–80 years) undergoing elective transurethral resection of bladder tumor under general anesthesia at Osijek University Hospital. Researchers will collect blood samples around the time of surgery to measure circulating biomarkers related to neurodegeneration and oxidative stress and will monitor patients for perioperative cognitive changes using questionnaires and testing. The study will record relevant exposures such as smoking, occupational solvent or dye exposure, comorbidities, and frailty to explore associations. No experimental treatments are given; the project looks for relationships between biomarkers and postoperative cognitive outcomes.
Who should consider this trial
Good fit: Adults aged 18 to 80 scheduled for elective transurethral resection of bladder tumor under general anesthesia who can understand and sign informed consent and complete questionnaires.
Not a fit: People under 18 or over 80, those undergoing emergency surgery, or patients unable to communicate or provide informed consent are not eligible and will not benefit from participation.
Why it matters
Potential benefit: If successful, identifying blood markers could help predict who is at higher risk of postoperative cognitive problems so clinicians can monitor or adjust care.
How similar studies have performed: Previous observational work has suggested links between certain blood biomarkers and postoperative cognitive decline, but results have been mixed and the approach is not yet definitive.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult patients from 18-80 years, * elective operations of tumor bladder cancer (TUR), * patients can communicate, * patients who can sign the information consent and questionnaires Exclusion Criteria: * patients under the age of 18, * patients above 80 years, * patients who are unable to communicate * patients who do not understand informed consent for the research, * patients who are unable to write * emergency surgery, * patients with proven hypersensitivity to some of the drugs used in the study * patients in a state of shock, septic, or hemorrhagic patients with neurodevelopmental disorders
Where this trial is running
Osijek, Croatia
- Osijek UH — Osijek, Croatia, Croatia (RECRUITING)
Study contacts
- Study coordinator: Ana Cicvarić
- Email: annikaadv@gmail.com
- Phone: +385 511 502
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cognitive Decline, Urinary Bladder Cancer, Frail, Biomarker, General Anesthesia, Hand Grip Strength, Cognitive Testing, Comorbidities