Blood and cyst fluid analysis from patients undergoing pancreatic cyst surgery
Official title: Pilot Proof of Concept Study of miRNA and Protein Signatures in Exosomes From Blood and Cystic Fluid in Patients Undergoing Surgery for Worrisome Pancreatic Cysts
Run by Translational Genomics Research Institute · NCT07767227 · Data updated 2026-11-12
Researchers will collect blood and cyst fluid from adults having pancreatic cysts surgically removed to test for DNA, RNA, and proteins.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Translational Genomics Research Institute Academic / other |
| Locations | 2 sites (Newport Beach, California and 1 other locations) |
| Status | Recruiting |
| Started | February 3, 2025 |
| Main results expected | December 2027 |
| Study ends | March 2028 |
| Registry record updated | August 17, 2026 |
| Trial ID | NCT07767227 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with a radiologically documented pancreatic cyst that is recommended for surgical resection and who consent to sample collection.
✕Probably not a fit
Patients who are not undergoing surgery or who do not consent to sample collection may not benefit from the study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study collects biospecimens (blood and cyst fluid) and related data from participants with pancreatic cysts who are already scheduled for surgical removal. Samples will be analyzed to explore the molecular content, including DNA, RNA, and proteins, to better understand the cysts. The study does not involve an experimental treatment and relies on standard surgical indications. Participation requires informed consent and adherence to study procedures. The research is conducted across multiple institutions with specified recruitment sites.
Why it matters
Potential benefit: Possible insights into the molecular characteristics of pancreatic cysts that could inform future diagnostics or risk stratification.
How similar studies have gone: Prior studies have shown that analyzing cyst fluid and blood can reveal useful molecular information; this approach is established but not universally applied to all cyst types.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Voluntarily agree to participate by giving written informed consent prior to any study-specific procedures. * Subject at least 18 years of age and able to provide consent. Subject is willing and able to comply with requirements of the protocol. * Radiologically documented cyst of the pancreas for which surgical removal is clinically indicated. * Patient will be undergoing a surgical resection of their pancreatic cystic neoplasm. Exclusion Criteria: * Patient who is pregnant at the time of study enrollment and sample collection. * Patient will not be undergoing clinically indicated surgery for a pancreatic cystic neoplasm. * Patient is unwilling or unable to provide informed consent or comply with study procedures.
Where it's running
-
Hoag Family Cancer Institute
Newport Beach, California, United States Recruiting -
Piedmont HealthCare
Atlanta, Georgia, United States Recruiting
Study contacts
- Principal investigator: Michael Demeure, MD — Hoag Family Cancer Institute
- Study coordinator: Michael Demeure, MD
- Email: clinicalresearch@hoag.org
- Phone: 949-764-4577
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.