Biorepository for studying kidney disease in individuals with ApoL1 mutations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Duke ApoL1 Nephropathy Biorepository focuses on understanding end stage kidney disease (ESKD) by collecting samples from individuals with and without kidney disease, particularly those of African ancestry. This observational study aims to explore the genetic factors, specifically mutations in the ApoL1 gene, that contribute to the higher prevalence of kidney failure in this population. By utilizing advanced techniques to create kidney-like cells from induced pluripotent stem cells (iPSCs), researchers hope to uncover the mechanisms linking these mutations to kidney disease. The study will include both affected individuals and healthy controls to provide a comprehensive understanding of the condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Majority of subjects recruited for this study will be self-identified African Americans, Afro-Caribbean and other black individuals. Study subjects will include individuals at various stages of kidney disease and those without any clinical evidence of kidney disease.
* Healthy black adults, age 50 and older with no known history of kidney disease will be recruited as controls

Exclusion Criteria:

* Black adult cases with diabetic nephropathy
* Healthy controls with kidney disease

Where it's running

• Duke University Medical Center
  Durham, North Carolina, United States Recruiting

Study contacts

• Study coordinator: Opeyemi Olabisi, MD/PHD
• Email: opeyemi.olabisi@duke.edu
• Phone: 919-660-6987

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.