Better care for people with recent-onset stable chest pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

IMPRO is a stepped-wedge interventional implementation trial testing a new cross-sectoral care model (NVF) across 16 regions in 12 German federal states to increase guideline-based use of coronary CT for suspected coronary artery disease. The model aims to improve primary and cross-sectoral pathways so eligible patients with recent-onset stable chest pain can receive coronary CT as a less invasive diagnostic alternative to routine cardiac catheterisation. The trial will compare cardiovascular events, patient responses, and healthcare costs before and after NVF rollout, excluding patients with known obstructive CAD, recent negative coronary imaging, or acute coronary syndrome. The project is funded for 39 months with roughly €9.3 million in support.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥30 years
* Suspected CAD with stable chest pain
* Ability to give informed consent

Exclusion Criteria:

* Known or previously treated (with PCI or CABG) obstructive CAD (defined as at least one coronary diameter stenosis ≥50%)
* Acute coronary syndrome
* Negative invasive coronary angiography or coronary CT within the last 5 years
* Already enrolled in the study
* Not covered by statutory health insurance
* Unable to give consent

Where it's running

• Universitätsklinikum Augsburg, Diagnostische und Interventionelle Radiologie und Neuroradiologie
  Augsburg, Germany Recruiting
• Universitätsklinikum Augsburg, Institut für Allgemeinmedizin
  Augsburg, Germany Recruiting
• RHOEN-Klinikum AG, Campus Bad Neustadt, Klinik für Radiologie
  Bad Neustadt an der Saale, Germany Recruiting
• Charité-Universitätsmedizin Berlin, Institut für Allgemeinmedizin
  Berlin, Germany Recruiting
• Charité - Universitätsmedizin Berlin, Klinik für Radiologie
  Berlin, Germany Recruiting
• Uniklinik Köln, Institut für Diagnostische und Interventionelle Radiologie
  Cologne, Germany Recruiting

Study contacts

• Principal investigator: Annika Viniol, Prof. Dr. — Philipps-Universität Marburg, Institut für Allgemeinmedizin
• Study coordinator: Annika Viniol, Prof. Dr.
• Email: annika.viniol@staff.uni-marburg.de
• Phone: +49 6421 28-65120

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.